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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis

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Autor(es):
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Nascimento, C. [1] ; Di Lorenzo Alho, A. T. [2, 3] ; Bazan Conceicao Amaral, C. [4] ; Leite, R. E. P. [5] ; Nitrini, R. [6] ; Jacob-Filho, W. [5] ; Pasqualucci, C. A. [4] ; Hokkanen, S. R. K. [7] ; Hunter, S. [7] ; Keage, H. [8] ; Kovacs, G. G. [9] ; Grinberg, L. T. [4, 10] ; Suemoto, C. K. [5]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Med Sch, Dept Psychiat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Dept Radiol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Hosp lsraelita Albert Einstein, Med Sch, Inst Cerebro, Sao Paulo - Brazil
[4] Univ Sao Paulo, Med Sch, Dept Pathol, Sao Paulo - Brazil
[5] Univ Sao Paulo, Med Sch, Div Geriatr, Sao Paulo - Brazil
[6] Univ Sao Paulo, Med Sch, Dept Neurol, Sao Paulo - Brazil
[7] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge - England
[8] Univ South Australia, Sch Psychol, Social Work & Social Policy, Adelaide, SA - Australia
[9] Med Univ Vienna, Inst Neurol, Vienna - Austria
[10] Univ San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94117 - USA
Número total de Afiliações: 10
Tipo de documento: Artigo de Revisão
Fonte: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY; v. 44, n. 3, p. 286-297, APR 2018.
Citações Web of Science: 10
Resumo

ObjectiveTo perform a systematic review and meta-analysis on the prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults. MethodsWe systematically reviewed and performed a meta-analysis on the prevalence of TDP-43 proteinopathy in older adults with normal cognition, evaluated by the Mini-Mental State Examination or the Clinical Dementia Rating. We estimated the overall prevalence of TDP-43 using random-effect models, and stratified by age, sex, sample size, study quality, antibody used to assess TDP-43 aggregates, analysed brain regions, Braak stage, Consortium to Establish a Registry for Alzheimer's Disease score, hippocampal sclerosis and geographic location. ResultsA total of 505 articles were identified in the systematic review, and 7 were included in the meta-analysis with 1196 cognitively normal older adults. We found an overall prevalence of TDP-43 proteinopathy of 24%. Prevalence of TDP-43 proteinopathy varied widely across geographic location (North America: 37%, Asia: 29%, Europe: 14%, and Latin America: 11%). Estimated prevalence of TDP-43 proteinopathy also varied according to study quality (quality score >7: 22% vs. quality score <7: 42%), antibody used to assess TDP-43 proteinopathy (native: 18% vs. hyperphosphorylated: 24%) and presence of hippocampal sclerosis (without 24% vs. with hippocampal sclerosis: 48%). Other stratified analyses by age, sex, analysed brain regions, sample size and severity of AD neuropathology showed similar pooled TDP-43 prevalence. ConclusionsDifferent methodology to access TDP-43, and also differences in lifestyle and genetic factors across different populations could explain our results. Standardization of TDP-43 measurement, and future studies about the impact of genetic and lifestyle characteristics on the development of neurodegenerative diseases are needed. (AU)

Processo FAPESP: 15/17365-7 - Desvendando as bases moleculares relacionadas ao acúmulo da proteína TDP-43: um estudo com foco em abordagens terapêuticas
Beneficiário:Camila Nascimento Mantelli
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 11/19833-7 - Caracterização das alterações da proteína TDP-43 durante o envelhecimento normal: uma análise em cérebros humanos postmortem
Beneficiário:Camila Nascimento Mantelli
Linha de fomento: Bolsas no Brasil - Doutorado