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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Influence of Prior Knowledge of Human Papillomavirus Status on the Performance of Cytology Screening

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Autor(es):
Martins, Toni Ricardo [1, 2] ; Longatto-Filho, Adhemar [3, 4, 5, 6, 7] ; Cohen, Diane [8] ; Kodaira Viscondi, Juliana Yukari [9] ; Fuza, Luiz Mario [1, 8] ; Cury, Lise [8] ; Villa, Luisa Lina [10, 6, 11] ; Levi, Jose Eduardo [1, 6] ; Eluf-Neto, Jose [9, 8, 6]
Número total de Autores: 9
Afiliação do(s) autor(es):
Mostrar menos -
[1] Univ Sao Paulo, Inst Trop Med, Virol Lab, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Infect Dis, Sch Med, Sao Paulo - Brazil
[3] ICVS 3Bs PT Govt Associate Lab, Braga - Portugal
[4] Univ Sao Paulo, Fac Med, Lab Med Invest LIM 14, Sao Paulo - Brazil
[5] Pio XII Fdn, Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos - Brazil
[6] Inst Nacl Ciencia & Tecnol Doencas Papilomavirus, Sao Paulo - Brazil
[7] Univ Minho, Sch Hlth Sci, Liffe & Hlth Sci Res Inst ICVS, Braga - Portugal
[8] Fundacao Oncoctr Sao Paulo, Oscar Freire St 2396, BR-05409012 Sao Paulo, SP - Brazil
[9] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo - Brazil
[10] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo - Brazil
[11] Inst Canc Estado Sao Paulo, Ctr Invest Translac Oncol, Sao Paulo - Brazil
Número total de Afiliações: 11
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF CLINICAL PATHOLOGY; v. 149, n. 4, p. 316-323, APR 2018.
Citações Web of Science: 1
Resumo

Objectives: This study aimed to evaluate the influence of prior knowledge of human papillomavirus (HPV) status in cervical cytopathology readings. Methods: Participants comprised 2,376 women who underwent parallel cytology and HPV-DNA testing. Smears were read twice by the same team, first with previous knowledge of HPV-DNA status. Results: Overall, 239 (10.2%) smears had their cytology classification altered by the HPV-informed review. Cytology readings with prior knowledge of the HPV status revealed 10.5% of abnormal smears (atypical squamous cells of undetermined significance or higher), while without prior knowledge, this rate dropped to 7.6%. When HPV status was informed, a significant increase in all categories of altered smears was observed. Cytology with prior knowledge of HPV status detected more cervical intraepithelial neoplasia grade 2 or higher (CIN 2+) compared with blinded: 86.7% vs 60.0%. Conclusions: Our data indicate that cytology interpreted with prior knowledge of the HPV status provides higher sensitivity for CIN 2+ lesions while marginally reducing the overall specificity compared with HPV status blinded cytology. (AU)

Processo FAPESP: 08/57889-1 - Instituto de Ciência e Tecnologia para o Estudo das Doenças Associadas ao Papilomavírus
Beneficiário:Luisa Lina Villa
Modalidade de apoio: Auxílio à Pesquisa - Temático