Fibroblast and pre-osteoblast cell adhesive behavior on titanium alloy coated with diamond film

Autor(es)

Silva, William de Melo ^{[1, 2]} ; Ribeiro, Camila Amorim ^[1] ; Marques, Cleiton Silva ^[2] ; Tabata, Americo Sheitiro ^[3] ; Saeki, Margarida Juri ^[4] ; Medeiros, Leonardo Iusuti ^[5] ; de Oliveira, Deilson Elgui ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista Julio Mesquita Filho UNESP, Dept Bioproc & Biotecnol, Rua Jose Barbosa Barros 1780, BR-1861030 Botucatu, SP - Brazil

^[2] Univ Estadual Paulista Julio Mesquita Filho UNESP, Fac Med Botucatu, Inst Biotecnol IBTEC, Botucatu, SP - Brazil

^[3] Univ Estadual Paulista Julio Mesquita Filho UNESP, Fac Ciencias, Dept Fis, Bauru, SP - Brazil

^[4] Univ Estadual Paulista Julio Mesquita Filho UNESP, Inst Biociencias, Dept Quim & Bioquim, Botucatu, SP - Brazil

^[5] Univ Estadual Santa Cruz, Dept Ciencias Exatas & Tecnol DCET, Ilheus, BA - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 20, n. 2, p. 284-290, 2017.
• Citações Web of Science: 1

Resumo

It is well known that titanium alloys have mechanical strengths comparable to steels, as well as high corrosion resistance. Also, they have the advantage of promoting osseointegration, when used in medical and dental implants. This work aims to describe the adhesion properties of fibroblast and osteoblast cells on the surface of titanium aluminum vanadium alloy (Ti6Al4V). Three different conditions of the surface were investigated: smooth, rough and covered with diamond film. Conventional material characterizations were performed to the film which consisted in: Morphological visualization by scanning electron microscopy, confocal profilometry, X-ray diffraction pattern, Raman backscattering spectroscopy and atomic force microscopy. Biocompatibility tests of Ti6Al4V were performed using primary human fibroblasts and mouse pre-osteoblasts cell line MC3T3-E1. Overall, diamond films deposited on Ti6Al4V showed interesting results of uniformity and protection against cracks on to the surface, reasonable biocompatibility features if compared to uncovered ones, indicating that this film is an alternative for using in health care applications. (AU)

• Processo FAPESP: 15/20438-6 - Modificação de superfície de aços inoxidáveis, titânio puro e ligado para a prevenção da formação de biofilme: um estudo comparativo entre a engenharia de superfície e o uso de antibióticos
• Beneficiário: William de Melo Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular