Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity

Texto completo
Autor(es):
Mostrar menos -
Saia Cereda, Cintia Maria [1] ; Mecatti, Daniel Sebbe [2] ; Boava Papini, Juliana Zampoli [1] ; Bueno, Diego Valerio [2] ; Franz-Montan, Michelle [3] ; Rocha, Thalita [2] ; Pedrazzoli Junior, Jose [2] ; de Paula, Eneida [4] ; de Araujo, Daniele Ribeiro [5] ; Grillo, Renato [6] ; Fraceto, Leonardo Fernandes [7] ; Calafatti, Silvana Aparecida [2] ; Tofoli, Giovana Radomille [1]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Inst & Res Ctr Sao Leopoldo Mandic, Rua Jose Rocha Junqueira 13, BR-1304575 Campinas, SP - Brazil
[2] Sao Francisco Univ, UNIFAG, Braganca Paulista, SP - Brazil
[3] Univ Estadual Campinas, Dept Physiol Sci, Piracicaba, SP - Brazil
[4] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[5] Fed Univ ABC, Human & Nat Sci Ctr, Santo Andre, SP - Brazil
[6] Sao Paulo State Univ UNESP, Sch Engn, Dept Phys & Chem, Ilha Solteira, SP - Brazil
[7] Sao Paulo State Univ UNESP, Dept Environm Engn, Sorocaba, SP - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PAIN RESEARCH; v. 11, p. 683-691, 2018.
Citações Web of Science: 2
Resumo

Objective: This study reports a preclinical evaluation of an alginate/chitosan nanoparticle formulation containing NovaBupi (R), a racemic bupivacaine (BVC) containing 25% dextrobupivacaine and 75% levobupivacaine. Methods: New Zealand White rabbits (n=6) received intraoral or intrathecal injections of BVC 0.5% or BVC 0.5%-loaded alginate-chitosan nanoparticles (BVCALG). BVC plasma levels and pharmacokinetic parameters were determined in blood samples of these rabbits. An infraorbital nerve blockade was performed in male Wistar rats (n=7) with the same formulations and the vehicle (NPALG). Histological evaluation of local toxicity after 6 hours and 24 hours of the treatments was performed in rats' (n=6) oral tissues. Results: No statistically significant difference was observed between plasma concentrations and pharmacokinetic parameters (p>0.05) after intraoral injections. However, after intrathecal injection BVCALG changed approximately three times the values of volume of distribution and area under the curve (AUC(0-t); p<0.05). The total analgesic effect of BVC after infraorbital nerve blockade was improved by 1.4-fold (p<0.001) with BVCALG. BVC and BVCALG did not induce significant local inflammatory reaction. Conclusion: The encapsulation of BVC prolongs the local anesthetic effect after infraorbital nerve blockade and altered the pharmacokinetics after intrathecal injection. (AU)

Processo FAPESP: 14/14457-5 - Carreadores baseados em lipídios (SLN/NLC e lipossomas com gradiente iônico) como estratégia para aumentar a encapsulação e a potência de anestésicos locais
Beneficiário:Eneida de Paula
Linha de fomento: Auxílio à Pesquisa - Temático