Reduced Gray Matter Volume of the Thalamus and Hippocampal Region in Elderly Healthy Adults with no Impact of APOE epsilon 4: A Longitudinal Voxel-Based Morphometry Study

Autor(es)

Squarzoni, Paula ^{[1, 2]} ; Souza Duran, Fabio Luis ^{[1, 2]} ; Busatto, Geraldo F. ^{[1, 2]} ; Toledo de Ferraz Alves, Tania Correa ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, NAPNA, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Psychiat, Lab Psychiat Neuroimaging LM 21, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ALZHEIMER'S DISEASE; v. 62, n. 2, p. 757-771, 2018.
• Citações Web of Science: 2

Resumo

Background: Many cross-sectional voxel-based morphometry (VBM) investigations have shown significant inverse correlations between chronological age and gray matter (GM) volume in several brain regions in healthy humans. However, few VBM studies have documentedGMdecrements in the healthy elderly with repeated MRI measurements obtained in the same subjects. Also, the extent to which the APOE epsilon 4 allele influences longitudinal findings of GM reduction in the healthy elderly is unclear. Objective: Verify whether regional GM changes are associated with significant decrements in cognitive performance taking in account the presence of the APOE epsilon 4 allele. Methods: Using structural MRI datasets acquired in 55 cognitively intact elderly subjects at two time-points separated by approximately three years, we searched for voxels showing significant GM reductions taking into account differences in APOE genotype. Results: We found global GM reductions as well as regional GM decrements in the right thalamus and left parahippocampal gyrus (p < 0.05, family-wise error corrected for multiple comparisons over the whole brain). These findings were not affected by APOE epsilon 4. Conclusions: Irrespective of APOE epsilon 4, longitudinal VBM analyses show that the hippocampal region and thalamus are critical sites where GM shrinkage is greater than the degree of global volume reduction in healthy elderly subjects. (AU)

• Processo FAPESP: 04/15336-5 - Alterações cerebrais associadas a fatores de risco cardiovascular: um estudo de base populacional usando morfometria voxel-a-voxel por ressonância magnética e medidas de metabolismo de glicose por tomografia por emissão de pósitrons
• Beneficiário: Geraldo Busatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/56464-9 - Centro de Imagem em Neurociências da Faculdade de Medicina da Universidade de São Paulo
• Beneficiário: Giovanni Guido Cerri
• Modalidade de apoio: Auxílio à Pesquisa - Programa CINAPCE - Temático
• Processo FAPESP: 13/03231-3 - Padrões de atrofia cortical e déficits cognitivos associados ao envelhecimento saudável: um estudo de seguimento por ressonância magnética estrutural
• Beneficiário: Paula Squarzoni da Silveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado