Multi-isotope calibration for inductively coupled plasma mass spectrometry

Autor(es)

Virgilio, Alex ^[1] ; Nobrega, Joaquim A. ^[1] ; Donati, George L. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Chem, Grp Appl Instrumental Anal, POB 676, BR-13565905 Sao Paulo - Brazil

^[2] Wake Forest Univ, Dept Chem, Salem Hall, POB 7486, Winston Salem, NC 27109 - USA

• Tipo de documento: Artigo Científico
• Fonte: ANALYTICAL AND BIOANALYTICAL CHEMISTRY; v. 410, n. 3, p. 1157-1162, JAN 2018.
• Citações Web of Science: 13

Resumo

Multi-isotope calibration (MICal) is a novel approach to calibration for inductively coupled plasma mass spectrometry (ICP-MS). In MICal, only two calibration solutions are required: solution A, composed of 50% v v(-1) of sample and 50% v v(-1) of a standard solution containing the analytes, and solution B, composed of 50% v v(-1) of sample and 50% v v(-1) of a blank solution. MICal is based on monitoring the signal intensities of several isotopes of the same analyte in solutions A and B. By plotting the analytical signals from solution A in the x-axis, and from solution B in the y-axis, the analyte concentration in the sample is calculated using the slope of that graph and the concentration of the reference standard added to solution A. As both solutions contain the same amount of sample, matrix-matching is easily achieved. In this proof-of-concept study, MICal was applied to the determination of Ba, Cd, Se, Sn, and Zn in seven certified reference materials with different matrices (e.g., plant materials, flours, and water). In most cases, MICal results presented no statistical difference from the certified values at a 95% confidence level. The new strategy was also compared with traditional calibration methods such as external calibration, internal standardization and standard additions, and recoveries were generally better for MICal. This is a simple, accurate, and fast alternative method for matrix-matching calibration in ICP-MS. (AU)

• Processo FAPESP: 14/18393-1 - Avaliação da análise em fluxo por gradiente como estratégia de calibração para técnicas espectroanalíticas com fonte de plasma
• Beneficiário: Alex Virgilio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado