Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Respiratory syncytial virus evaluation among asymptomatic and symptomatic subjects in a university hospital in Sao Paulo, Brazil, in the period of 2009-2013

Texto completo
Autor(es):
Moreira, Luciana Peniche [1] ; Aranha Watanabe, Aripuana Sakurada [1] ; Camargo, Clarice Neves [1] ; Melchior, Thais Boim [1] ; Granato, Celso [1] ; Bellei, Nancy [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Sao Paulo Fed Univ, Dept Med, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Influenza and Other Respiratory Viruses; v. 12, n. 3, p. 326-330, MAY 2018.
Citações Web of Science: 5
Resumo

Background: The respiratory syncytial virus (RSV) is recognized as an important cause of respiratory tract infections. Immunocompromised patients, healthcare workers (HCWs) and children contacts are at increased risk of acquiring the infection. However, the impact of asymptomatic infection in transmission has not been well studied. Objectives: this study evaluated the frequency and viral load (VL) of RSV in nasal swab samples of individuals with different risk factors for acquiring infection in a university hospital in Sao Paulo, Brazil. Methods: We included 196 symptomatic children and their 192 asymptomatic caregivers, 70 symptomatic and 95 asymptomatic HCWs, 43 samples from symptomatic HIV-positive outpatients, and 100 samples of asymptomatic HIV patients in the period of 2009-2013. Results: RSV infection was detected in 10.1% (70/696) of samples, 4.4% (17/387) of asymptomatic patients, and 17.1% (53/309) from symptomatic patients. (P < .0001). The VL of symptomatic patients (4.7 log copies/mL) was significantly higher compared to asymptomatic patients (2.3 log copies/mL). RSV detection among asymptomatic caregivers (6.8%; 13/192) was significantly higher compared to other asymptomatic adults, HIV and HCWs (2.0%; 4/195; P = .0252). A close contact with an infected child at home was an important risk to RSV acquisition {[}OR 22.6 (95% CI 4.8-106.7)]. Children who possibly transmitted the virus to their asymptomatic contacts had significantly higher viral load than children who probably did not transmit (P < .0001). Conclusions: According to our results, it is important to know if people circulating inside the hospital have close contact with acute respiratory infected children. (AU)

Processo FAPESP: 16/09279-6 - Avaliação da frequência dos poliomavírus WU e KI em populações atendidas em hospital terciário da cidade de São Paulo.
Beneficiário:Nancy Cristina Junqueira Bellei
Modalidade de apoio: Auxílio à Pesquisa - Regular