Hypertension induces additional cardiometabolic impairments and attenuates aerobic exercise training adaptations in fructose-fed ovariectomized rats

Autor(es)

Brito-Monzani, Janaina de O. ^[1] ; Sanches, Iris Callado ^[2] ; Bernardes, Nathalia ^[3] ; Ponciano, Katia ^[2] ; Moraes-Silva, Ivana C. ^[4] ; Irigoyen, Maria-Claudia ^[4] ; Llesuy, Susana ^[5] ; De Angelis, Katia ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Maranhao, Lab Cardiovasc Adaptat Exercise LACORE, Sao Luis - Brazil

^[2] Univ Sao Judas Tadeu, Sao Paulo - Brazil

^[3] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sci Rehabil Program, Rua Vergueiro 235-249-2 Subsolo Mestrado, BR-01504001 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Med Sch, Heart Inst InCor, Hypertens Unit, Sao Paulo - Brazil

^[5] Univ Buenos Aires, Fac Farm & Bioquim, Buenos Aires, DF - Argentina

• Tipo de documento: Artigo Científico
• Fonte: HYPERTENSION RESEARCH; v. 41, n. 2, p. 88-95, FEB 2018.
• Citações Web of Science: 1

Resumo

We tested whether hypertension favors the development of additional cardiometabolic changes in fructose-fed ovariectomized rats and how it affects aerobic exercise training (ET) effects. All rats received fructose in drinking water (10%) beginning at weaning, were ovariectomized at 10 weeks of age and divided into the normotensive sedentary (NFOS) and trained (NFOT) and hypertensive sedentary (HFOS) and trained (HFOT) groups. ET was performed on a treadmill. Arterial pressure (AP) was directly recorded; heart rate and AP variabilities were analyzed. Lipoperoxidation (LPO) and antioxidant enzyme levels were measured in the left ventricle. In addition to increased AP levels, when compared with the NFOS group, the hypertensive groups had resting tachycardia, a reduction of 29% in the pulse interval variance (VAR-PI), 19% in RMSSD (root mean square of successive differences, a cardiac parasympathetic index) and 53% in the a-index (spontaneous baroreflex), while the systolic AP variance (VAR-SAP) and its low-frequency band (LF-SAP) were sharply increased. ET did not alter AP levels. Even in the presence of hypertension, ET induced resting bradycardia, decreases of 33% in VAR-SAP and 49% in LF-SAP, and an increase of more than 60% in VAR-PI and the a-index. However, some of these parameters were still impaired relative to those of normotensive rats. LPO was reduced and catalase was increased in both trained groups, with no difference between the normotensive and hypertensive groups. Negative correlations were obtained between LPO and RMSSD (r=-0.60, Po0.05) and a-index (r=-0.63, Po0.05). In conclusion, hypertension augmented the dysfunctions in fructose-fed ovariectomized rats and attenuated metabolic aerobic ET benefits. These changes may be related to cardiovascular autonomic and oxidative stress alterations. (AU)

• Processo FAPESP: 12/20141-5 - Efeitos do treinamento físico aeróbio, resistido ou combinado em modelos experimentais de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/17188-4 - Mecanismos associados às disfunções em um modelo experimental de menopausa e síndrome metabólica: papel do treinamento físico aeróbio ou resistido
• Beneficiário: Janaina de Oliveira Brito
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/11223-6 - Curso temporal das alterações neuroimunes induzidas pelo consumo crônico de frutose em ratos normotensos e hipertensos: papel do treinamento físico aeróbio
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Regular