Colorimetric paper-based device for gaseous hydrogen cyanide quantification based on absorbance measurements

Autor(es)

da Silveira Petruci, Joao Flavio ^{[1, 2]} ; Hauser, Peter C. ^[2] ; Cardoso, Arnaldo Alves ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Analyt Chem, BR-14800970 Araraquara, SP - Brazil

^[2] Univ Basel, Dept Chem, Spitalstr 51, CH-4056 Basel - Switzerland

• Tipo de documento: Artigo Científico
• Fonte: SENSORS AND ACTUATORS B-CHEMICAL; v. 268, p. 392-397, SEP 1 2018.
• Citações Web of Science: 9

Resumo

Hydrogen cyanide is a highly toxic compound employed for applications such as electroplating, production of organic solvents, fish stunning, and even as a chemical weapon. In this work, we describe a new microfluidic paper-based assay for selective cyanide determination, based on the reaction of the cyanide anion with palladium dimethylglyoximate (DMG) followed by colorimetric reaction of DMG with nickel. Quantification was performed by measuring the absorbance of light passing through the paper, employing an LED emitting at 525 nm and a log ratio amplifier circuit emulating Lambert-Beer's law. This offers an alternative to the smartphone-based methodologies for signal treatment usually employed in colorimetric mu PAD-based methods The technique enabled linear calibration within the range 100-500 ppb of HCN, as well as a detection limit of 10 ppb for HCN in gaseous samples. The sampling time used for this concentration range was 5 min. The method was also tested for the quantification of cyanide in aqueous samples by adding H3PO4 to the sample, followed by exposure of the paper sensor to the gaseous HCN generated. A detection limit of 1 mu M was achieved, which makes the method also suitable for detection of cyanide in liquid samples. (C) 2018 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 15/23265-5 - Desenvolvimento de equipamento miniaturizado baseado mudança de propriedade óptica e gerenciamento por hardware livre para determinação de gases minoritários presente na atmosfera
• Beneficiário: Arnaldo Alves Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/16830-0 - Plataforma miniaturizada para sensores gasosos utilizando LED e dispositivos microfluídicos em papel
• Beneficiário: João Flávio da Silveira Petruci
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado