Associations between REV-ERB alpha, sleep duration and body mass index in European adolescents

Autor(es):Mostrar menos -

Nascimento Ferreira, Marcus Vinicius ^{[1, 2]} ; Goumidi, Louisa ^[3] ; Carvalho, Heraclito Barbosa ^[2] ; De Moraes, Augusto Cesar F. ^{[2, 4]} ; Santaliestra-Pasias, Alba M. ^[1] ; Kafatos, Anthony ^[5] ; Molnar, Denes ^[6] ; Lambrinou, Christina-Paulina ^[7] ; De Henauw, Stefaan ^[8] ; Gutierrez, Angel ^[9] ; Censi, Laura ^[10] ; Marcos, Ascension ^[11] ; Widhalm, Kurt ^[12] ; Gottrand, Frederic ^[13] ; Gonzalez-Gross, Marcela ^{[14, 15]} ; Meirhaeghe, Aline ^[3] ; Moreno, Luis A. ^[1] ; Grp, HELENA Study

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, IA2, Inst Invest Sanitaria Aragon IIS Aragon, Ctr Inves, Zaragoza - Spain

^[2] Univ Sao Paulo, Fac Med, Youth Child Cardiovasc Risk & Environm YCARE Res, Sao Paulo, SP - Brazil

^[3] Univ Lille, INSERM, Inst Pasteur Lille, RID AGE Risk Factors & Mol Determinants Aging Rel, F-59000 Lille - France

^[4] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 - USA

^[5] Univ Crete, Sch Med, Prevent Med & Nutr Unit, Heraklion, Crete - CRETE

^[6] Univ Pecs, Fac Med, Dept Pediat, Pecs - Hungary

^[7] Harokopio Univ, Dept Nutr & Dietet, Athens - Greece

^[8] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, Ghent - Belgium

^[9] Univ Granada, Sch Med, Dept Physiol, Granada - Spain

^[10] CREA Res Ctr Food & Nutr, Rome - Italy

^[11] Spanish Natl Res Council, Food Sci & Technol & Nutr Inst, Dept Metab & Nutr, Immunonutr Res Grp, Madrid - Spain

^[12] Private Med Univ Salzburg, Dept Pediat, Salzburg - Austria

^[13] Univ Lille 2, INSERM, U995, Lille - France

^[14] Tech Univ Madrid, Fac Phys Act & Sport INEF, Dept Hlth & Human Performance, Madrid - Spain

^[15] Rheinische Friedrich Wilhelms Univ Bonn, Inst Ernahrungs & Lebensmittelwissensch Humanerna, Bonn - Germany

• Tipo de documento: Artigo Científico
• Fonte: Sleep Medicine; v. 46, p. 56-60, JUN 2018.
• Citações Web of Science: 0

Resumo

Background/Objective: Although the REV-ERB alpha is considered an important regulator of both clock function and metabolism, its relationship with sleep duration and obesity is less clear. The objective of this study was to examine the association between the REV-ERB alpha clock gene and two outcomes - sleep duration and body mass index (BMI) - in European adolescents. Methods: A sample of 831 adolescents (392 boys) aged 11.5-18.8 years from 10 European centers was used. The independent variables were REV-ERB alpha rs2071427 and rs2071570 SNPs, and their respective haplotypes. The outcomes were sleep duration and BMI. Results: In girls, no significant association were found between rs2071427 or rs2071570 and the studied outcomes (p >= 0.43). In boys, however, significant associations were found between rs2071570 and sleep duration (beta: -0.32 h/day for T minor allele carriers; p = 0.0017), and rs2071427 and BMI (beta: +0.72 kg/m(2) for A minor allele carriers; p = 0.016). In the haplotype analysis, the TA haplotype (carrying the two minor alleles) was associated with both lower sleep duration (Delta = -0.38 h/day; p = 0.05) and higher BMI (Delta = +1.41 kg/m(2); p = 0.018) in boys, when compared with the common CC haplotype. Conclusions: The REV-ERB alpha rs2071427 and rs2071570 were associated with both sleep duration and BMI in boys. These findings confirmed the relevance of the REV-ERB alpha gene in human obesity, primarily in males, and also suggested that it has a potential role in affecting sleep duration. (C) 2018 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 16/18436-8 - Mensuração de níveis de gasto energético em crianças e adolescentes: validação de métodos para estudos epidemiológicos
• Beneficiário: Marcus Vinicius Nascimento Ferreira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/11468-6 - Desenho e implementação do Estudo SAYCARE: South American Youth/Child Cardiovascular and Environmental Study
• Beneficiário: Heraclito Barbosa de Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/25233-0 - Desenvolvimento e validação de métodos para avaliação do consumo alimentar e composição corporal em um estudo multicêntrico: SAYCARE study
• Beneficiário: Tara Rendo Urteaga
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/11732-3 - Abordagem estatística em estudos de validação de comportamentos relacionados ao gasto energético: concordância entre teoria e prática
• Beneficiário: Marcus Vinicius Nascimento Ferreira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 15/11406-3 - SAYCARE: South American Youth/Child cardiovascular and environmental study
• Beneficiário: Heraclito Barbosa de Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional
• Processo FAPESP: 15/14319-4 - Comportamentos relacionados com o balanço energético no SAYCARE study - comparação e concordância entre mensurações objetivas e auto-referida: métodos estatísticos a validação
• Beneficiário: Augusto César Ferreira de Moraes
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado