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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Associations between REV-ERB alpha, sleep duration and body mass index in European adolescents

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Nascimento Ferreira, Marcus Vinicius [1, 2] ; Goumidi, Louisa [3] ; Carvalho, Heraclito Barbosa [2] ; De Moraes, Augusto Cesar F. [2, 4] ; Santaliestra-Pasias, Alba M. [1] ; Kafatos, Anthony [5] ; Molnar, Denes [6] ; Lambrinou, Christina-Paulina [7] ; De Henauw, Stefaan [8] ; Gutierrez, Angel [9] ; Censi, Laura [10] ; Marcos, Ascension [11] ; Widhalm, Kurt [12] ; Gottrand, Frederic [13] ; Gonzalez-Gross, Marcela [14, 15] ; Meirhaeghe, Aline [3] ; Moreno, Luis A. [1] ; Grp, HELENA Study
Total Authors: 18
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[1] Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, IA2, Inst Invest Sanitaria Aragon IIS Aragon, Ctr Inves, Zaragoza - Spain
[2] Univ Sao Paulo, Fac Med, Youth Child Cardiovasc Risk & Environm YCARE Res, Sao Paulo, SP - Brazil
[3] Univ Lille, INSERM, Inst Pasteur Lille, RID AGE Risk Factors & Mol Determinants Aging Rel, F-59000 Lille - France
[4] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 - USA
[5] Univ Crete, Sch Med, Prevent Med & Nutr Unit, Heraklion, Crete - CRETE
[6] Univ Pecs, Fac Med, Dept Pediat, Pecs - Hungary
[7] Harokopio Univ, Dept Nutr & Dietet, Athens - Greece
[8] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, Ghent - Belgium
[9] Univ Granada, Sch Med, Dept Physiol, Granada - Spain
[10] CREA Res Ctr Food & Nutr, Rome - Italy
[11] Spanish Natl Res Council, Food Sci & Technol & Nutr Inst, Dept Metab & Nutr, Immunonutr Res Grp, Madrid - Spain
[12] Private Med Univ Salzburg, Dept Pediat, Salzburg - Austria
[13] Univ Lille 2, INSERM, U995, Lille - France
[14] Tech Univ Madrid, Fac Phys Act & Sport INEF, Dept Hlth & Human Performance, Madrid - Spain
[15] Rheinische Friedrich Wilhelms Univ Bonn, Inst Ernahrungs & Lebensmittelwissensch Humanerna, Bonn - Germany
Total Affiliations: 15
Document type: Journal article
Source: Sleep Medicine; v. 46, p. 56-60, JUN 2018.
Web of Science Citations: 0

Background/Objective: Although the REV-ERB alpha is considered an important regulator of both clock function and metabolism, its relationship with sleep duration and obesity is less clear. The objective of this study was to examine the association between the REV-ERB alpha clock gene and two outcomes - sleep duration and body mass index (BMI) - in European adolescents. Methods: A sample of 831 adolescents (392 boys) aged 11.5-18.8 years from 10 European centers was used. The independent variables were REV-ERB alpha rs2071427 and rs2071570 SNPs, and their respective haplotypes. The outcomes were sleep duration and BMI. Results: In girls, no significant association were found between rs2071427 or rs2071570 and the studied outcomes (p >= 0.43). In boys, however, significant associations were found between rs2071570 and sleep duration (beta: -0.32 h/day for T minor allele carriers; p = 0.0017), and rs2071427 and BMI (beta: +0.72 kg/m(2) for A minor allele carriers; p = 0.016). In the haplotype analysis, the TA haplotype (carrying the two minor alleles) was associated with both lower sleep duration (Delta = -0.38 h/day; p = 0.05) and higher BMI (Delta = +1.41 kg/m(2); p = 0.018) in boys, when compared with the common CC haplotype. Conclusions: The REV-ERB alpha rs2071427 and rs2071570 were associated with both sleep duration and BMI in boys. These findings confirmed the relevance of the REV-ERB alpha gene in human obesity, primarily in males, and also suggested that it has a potential role in affecting sleep duration. (C) 2018 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 16/18436-8 - Measurement of energy expenditure levels in children and adolescents: validation of methods for studies epidemiologic
Grantee:Marcus Vinicius Nascimento Ferreira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/11468-6 - Design and implementation of the SAYCARE Study: South American Youth/Child Cardiovascular and Environmental Study
Grantee:Heraclito Barbosa de Carvalho
Support type: Regular Research Grants
FAPESP's process: 14/25233-0 - Development and validation of methods to assess dietary intake and body composition in a multicenter study: SAYCARE study
Grantee:Tara Rendo Urteaga
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/11732-3 - Statistical approach in the validation of energy balance-related behaviors: agreement between theory and practice
Grantee:Marcus Vinicius Nascimento Ferreira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/11406-3 - SAYCARE study: South American youth/child cardiovascular and environmental study
Grantee:Heraclito Barbosa de Carvalho
Support type: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 15/14319-4 - Energy balance-related behaviors in the SAYCARE study - compared and agreement to objective measurement and self-reported: a validation statistical methods
Grantee:Augusto César Ferreira de Moraes
Support type: Scholarships abroad - Research Internship - Post-doctor