Peptidase inhibitors in tick physiology

Autor(es)

Parizi, L. F. ^{[1, 2]} ; Ali, A. ^{[3, 4]} ; Tirloni, L. ^[1] ; Oldiges, D. P. ^[1] ; Sabadin, G. A. ^[1] ; Coutinho, M. L. ^{[1, 2]} ; Seixas, A. ^{[5, 6]} ; Logullo, C. ^{[5, 7, 8]} ; Termignoni, C. ^{[5, 1, 9]} ; Da Silva Vaz, Jr., I. ^{[5, 1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Rio Grande do Sul, Ctr Biotecnol, Porto Alegre, RS - Brazil

^[2] Univ Fed Rio Grande do Sul, Fac Vet, Porto Alegre, RS - Brazil

^[3] Univ Sao Paulo, Escola Enfermagem Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[4] Abdul Wali Khan Univ, Dept Zool, Mardan - Pakistan

^[5] Inst Nacl Ciencia & Tecnol Entomol Mol, Rio De Janeiro, RJ - Brazil

^[6] Univ Fed Ciencias Saude Porto Alegre, Dept Farmacociencias, Porto Alegre, RS - Brazil

^[7] Univ Estadual Norte Fluminense, Lab Quim & Funcao Prot & Peptideos CBB, Campos Dos Goytacazes, RJ - Brazil

^[8] Univ Estadual Norte Fluminense, Unidade Expt Anim, Campos Dos Goytacazes, RJ - Brazil

^[9] Univ Fed Rio Grande do Sul, Dept Bioquim, Porto Alegre, RS - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Medical and Veterinary Entomology; v. 32, n. 2, p. 129-144, JUN 2018.
• Citações Web of Science: 5

Resumo

Peptidase inhibitors regulate a wide range of physiological processes involved in the interaction between hematophagous parasites and their hosts, including tissue remodeling, the immune response and blood coagulation. In tick physiology, peptidase inhibitors have a crucial role in adaptation to improve parasitism mechanisms, facilitating blood feeding by interfering with defense-related host peptidases. Recently, a larger number of studies on this topic led to the description of several new tick inhibitors displaying interesting novel features, for example a role in pathogen transmission to the host. A comprehensive review discussing these emerging concepts can therefore shed light on peptidase inhibitor functions, their relevance to tick physiology and their potential applications. Here, we summarize and examine the general characteristics, functional diversity and action of tick peptidase inhibitors with known physiological roles in the tick-host-pathogen interaction. (AU)

• Processo FAPESP: 15/19281-5 - Elaboração de uma vacina quimérica multicomponente recombinante baseada em epitopos de carrapatos Rhipicephalus microplus
• Beneficiário: Abid Ali
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado