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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Prospective study of human herpesvirus 8 oral shedding, viremia, and serological status among human immunodeficiency virus seropositive and seronegative individuals in Sao Paulo, Brazil

Texto completo
Autor(es):
Braz-Silva, Paulo H. [1, 2] ; Tozetto-mendoza, Tania R. [1] ; Sumita, Laura M. [1] ; Freire, Wilton [1] ; Palmieri, Michelle [2] ; do Canto, Alan M. [2] ; Avelino-Silva, Vivian I. [3] ; Gallottini, Marina [4] ; Mayaud, Philippe [5] ; Pannuti, Claudio S. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, IMTSP, Lab Virol LIM 52, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Odontol FOUSP, Disciplina Patol Geral, Dept Estomatol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med FMUSP, Dept Molestias Infecciosas & Parasitarias, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Estomatol, Disciplina Patol Oral & Maxilofacial, Sao Paulo - Brazil
[5] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Clin Res, London - England
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ORAL MICROBIOLOGY; v. 9, OCT 15 2017.
Citações Web of Science: 1
Resumo

Human herpesvirus 8 (HHV-8) is a gamma-herpesvirus and etiological agent of all forms of Kaposi sarcoma (KS). Saliva may play an important role in HHV-8 transmission in specific populations. Little is known about HHV-8 oral shedding pattern and the possible correlation with the HHV-8 serological profile and viremia. A prospective study was conducted of HHV-8 salivary excretion among human immunodeficiency virus HIV-seronegative (n = 47) and -seropositive (n = 44) homosexual men and HIV-seropositive women (n = 32) over a 6-month period with monthly HHV-8 serologies (immunofluorescence assays to identify antibodies to latent and lytic HHV-8 viral proteins, and a whole-virus HHV-8 enzyme-linked immunosorbent assay {[}ELISA]), monthly HHV-8 DNA serum/plasma detection, and daily self-collected oral rinses for HHV-8-DNA detection using real-time polymerase chain reaction. HHV-8 seropositivity was 51.1%, 63.6%, and 37.5%, in the three studied groups. There was no case of HHV-8 DNA detection in serum/plasma. Intermittent detection of oral HHV-8 DNA was observed during 5.1% (110/2,160) of visits among 28% (18/64) of HHV-8-seropositive individuals, all of whom were males and HHV-8 ELISA seropositive. In immunologically controlled populations of Brazil, HHV-8 oral shedding was limited to HHV-8-seropositive men, occurred infrequently and intermittently, and was not linked to HHV-8 viremia, suggesting a limited potential for oral or blood transmission. (AU)

Processo FAPESP: 12/04303-5 - Dinâmica da excreção oral e viremia do herpesvírus 8 humano (HHV-8) em indivíduos HIV positivos e negativos
Beneficiário:Paulo Henrique Braz da Silva
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 12/04223-1 - Dinâmica da excreção oral e viremia do herpesvírus 8 humano (HHV-8) em indivíduos HIV positivos e negativos
Beneficiário:Claudio Sergio Pannuti
Linha de fomento: Auxílio à Pesquisa - Regular