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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Serum interleukin measurement may help identify thyroid cancer patients with active disease

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Autor(es):
Martins, Mariana Bonjiorno [1] ; Marcello, Marjory Alana [1] ; Batista, Fernando de Assis [1] ; Peres, Karina Colombera [1] ; Meneghetti, Murilo [1] ; Latham Ward, Mirela Andrea [1] ; Sa de Camargo Etchebehere, Elba Cristina [2] ; Montali da Assumpcao, Ligia Vera [3] ; Ward, Laura Sterian [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Campinas Unicamp, Fac Med Sci FCM, Lab Canc Mol Genet, 126 Tessalia Vieira Camargo St, Campinas, SP - Brazil
[2] Univ Campinas Unicamp, Fac Med Sci FCM, Dept Radiol, Div Nucl Med, 251 Vital Brazil St, Campinas, SP - Brazil
[3] Univ Campinas Unicamp, Fac Med Sci FCM, Dept Med, Div Endocrinol, 251 Vital Brazil St, Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: CLINICAL BIOCHEMISTRY; v. 52, p. 1-7, FEB 2018.
Citações Web of Science: 4
Resumo

Background: Investigate the clinical utility of serum interleukin dosages of IL-2, IL-2R, IL-4, IL-6, IL-6R, IL-8, IL10 and IL-12 in the diagnosis and characterization of patients with DTC. In particular, verify ILs utility in the identification of individuals who are evolving disease-free or with the active disease. Methods: We evaluated 200 patients with malignant nodules (100 patients disease-free and 100 patients with recurrence/active disease); 60 benign nodules and 100 healthy controls, serum levels were assessed by ELISA. Results: All ILs, but not IL-4, differentiated these three groups. We observed that IL-2, 2R and 10 serum concentrations were associated with thyroglobulin levels. Serum IL-2 was able to differentiate patients with active disease from the disease-free with a sensitivity of 98%, specificity of 58%, positive predictive value (PPV) of 70% and negative predictive value (NPV) of 97% (p = 0.0007). IL-6R levels differentiated patients with active disease from the disease-free patients with 56% sensitivity, 63% specificity, PPV of 60% and NPV of 59% (p < 0.0001). IL-8 values also distinguished patients with active disease from the disease-free ones with sensitivity of 50%, specificity of 76%, PPV of 68% and NPV of 60% (p = 0.0025); using IL-12, we obtained a sensitivity value of 73%, specificity of 66%, PPV of 68% and NPV of 71% (p < 0.0001). Furthermore, interleukin levels showed association with some tumor characteristics of aggressiveness. Conclusion: We suggest that the serum concentration of ILs may assist in the diagnosis and characterization of tumor malignancy helping identify patients with active disease who deserve closer medical attention. (AU)

Processo FAPESP: 12/22726-0 - Estudo das interleucinas pró-inflamatórias (IL-2, IL-2R, IL-6, IL-6R, IL-8, IL-12 A e B) e anti-inflamatórias (IL-4, IL-4R, IL-10) no carcinoma diferenciado da tiróide
Beneficiário:Laura Sterian
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/16830-0 - Estudo das interleucinas séricas IL-2, IL-4, IL-4R (receptor), IL-6, il-6r(receptor), IL-8, IL-10, IL-1² (a e b) no perfil clínico-patológico do carcinoma diferenciado da tiroide
Beneficiário:Mariana Bonjiorno Martins
Linha de fomento: Bolsas no Brasil - Doutorado