Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, Sao Paulo, Brazil

Autor(es)

Guimaraes, Lilian O. ^[1] ; Bajay, Miklos Maximiliano ^[2] ; Monteiro, Eliana F. ^[1] ; Wunderlich, Gerhard ^[3] ; Santos, Sidney E. ^[4] ; Kirchgatter, Karin ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Malaria Res Ctr, Inst Trop Med, Superintendence Endem Dis Control, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Dept Genet, Piracicaba, SP - Brazil

^[3] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo, SP - Brazil

^[4] Fed Univ Para, Lab Human & Med Genet, Belem, Para - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HUMAN IMMUNOLOGY; v. 79, n. 2, p. 101-108, FEB 2018.
• Citações Web of Science: 3

Resumo

The innate immune system governed by toll -like receptors (TLRs) provides the first line of defense against pathogens. Surface -localized TLR1 and TLR6 are known to detect parasite components. TLR encoding genes were shown to display signatures of recent positive selection in Europeans and might be involved in local adaptation at immune -related genes. To verify the influence of Brazilian population admixture on the distribution of polymorphisms in TLRs, we analyzed the genotype frequencies of 24 polymorphisms distributed across five TLR genes in a Southeastern Brazilian population where autochthonous cases of malaria occur in small foci of transmission. The estimation of ancestry showed mainly European ancestry (63%) followed by African ancestry (22%). Mean proportions of European ancestry differed significantly between the genotypes of the TLR1 (1602S) gene and in the TLR6 (P249S) gene. The chance of having the G allele in TLR1 gene increases as European ancestry increases as well as the chance of having the T allele in the TLR6 gene. The 602S allele is related to a ``hypo -responsiveness{''} possibly explaining the high prevalence of asymptomatic malaria cases in areas of Southeastern Brazil. Our results underline the necessity to include informative ancestry markers in genetic association studies in order to avoid biased results. (AU)

• Processo FAPESP: 11/50492-1 - Estudo de polimorfismos geneticos em genes relacionados com a imunidade inata em populacao de area de baixa endemicidade para malaria.
• Beneficiário: Karin Kirchgatter Hildebrand
• Linha de fomento: Auxílio à Pesquisa - Regular