Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors

Autor(es)

Abrahao-Machado, Lucas Faria ^[1] ; Antunes, Bruno ^[2] ; Filippi, Renee Zon ^[3] ; Volc, Sahlua ^[4] ; Boldrini, Erica ^[5] ; Menezes, Weder P. ^[6] ; Reis, Rui M. ^{[7, 6, 8]} ; de Camargo, Olavo Pires ^[3]

Afiliação do(s) autor(es)

^[1] Barretos Canc Hosp, Dept Pathol & Mol Diag, Barretos, SP - Brazil

^[2] Barretos Canc Hosp, Dept Othoped Surg, Barretos, SP - Brazil

^[3] Univ Sao Paulo FMUSP, Fac Med, Inst Orthoped & Traumatol, Sao Paulo, SP - Brazil

^[4] Barretos Canc Hosp, Oncol Dept, Barretos, SP - Brazil

^[5] Barretos Canc Hosp, Pediat Dept, Barretos, SP - Brazil

^[6] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, SP - Brazil

^[7] ICVS 3Bs PT Govt Associate Lab, Braga - Portugal

^[8] Univ Minho, Hlth Sci Sch, Life & Hlth Sci Res Inst ICVS, Braga - Portugal

• Tipo de documento: Artigo Científico
• Fonte: BIOMARKERS IN MEDICINE; v. 12, n. 1, p. 35-44, JAN 2018.
• Citações Web of Science: 0

Resumo

Aim: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. Methods: Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival (OS). Results: Loss of MTAP expression was significantly associated with lower OS in both univariate and multivariate analyses. Conclusion: Loss of MTAP expression is an independent negative prognostic biomarker in ESFT. (AU)

• Processo FAPESP: 16/06833-2 - Caracterização molecular de MTAP (Methylthioadenosine phosphorylase) e avaliação do seu potencial terapêutico em gliomas
• Beneficiário: Weder Pereira de Menezes
• Modalidade de apoio: Bolsas no Brasil - Doutorado