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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors

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Author(s):
Abrahao-Machado, Lucas Faria [1] ; Antunes, Bruno [2] ; Filippi, Renee Zon [3] ; Volc, Sahlua [4] ; Boldrini, Erica [5] ; Menezes, Weder P. [6] ; Reis, Rui M. [7, 6, 8] ; de Camargo, Olavo Pires [3]
Total Authors: 8
Affiliation:
[1] Barretos Canc Hosp, Dept Pathol & Mol Diag, Barretos, SP - Brazil
[2] Barretos Canc Hosp, Dept Othoped Surg, Barretos, SP - Brazil
[3] Univ Sao Paulo FMUSP, Fac Med, Inst Orthoped & Traumatol, Sao Paulo, SP - Brazil
[4] Barretos Canc Hosp, Oncol Dept, Barretos, SP - Brazil
[5] Barretos Canc Hosp, Pediat Dept, Barretos, SP - Brazil
[6] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, SP - Brazil
[7] ICVS 3Bs PT Govt Associate Lab, Braga - Portugal
[8] Univ Minho, Hlth Sci Sch, Life & Hlth Sci Res Inst ICVS, Braga - Portugal
Total Affiliations: 8
Document type: Journal article
Source: BIOMARKERS IN MEDICINE; v. 12, n. 1, p. 35-44, JAN 2018.
Web of Science Citations: 0
Abstract

Aim: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. Methods: Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival (OS). Results: Loss of MTAP expression was significantly associated with lower OS in both univariate and multivariate analyses. Conclusion: Loss of MTAP expression is an independent negative prognostic biomarker in ESFT. (AU)

FAPESP's process: 16/06833-2 - Molecular characterization of MTAP (Methylthioadenosine phosphorylase) and evaluation of therapeutic potential in gliomas
Grantee:Weder Pereira de Menezes
Support Opportunities: Scholarships in Brazil - Doctorate