| Texto completo | |
| Autor(es): |
Marqueti, Rita C.
[1]
;
Durigan, Joao L. Q.
[1]
;
Oliveira, Anderson Jose S.
[1]
;
Mekaro, Marcelo Shinyu
[2]
;
Guzzoni, Vinicius
[2]
;
Aro, Andrea A.
[3]
;
Pimentel, Edson Rosa
[3, 4]
;
Selistre-de-Araujo, Heloisa S.
[2]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Brasilia UnB, Campus Univ, Ctr Metropolitano 1, Conjunto A, BR-72220900 Brasilia, DF - Brazil
[2] Fed Univ Sao Carlos UFSCar, Sao Carlos, SP - Brazil
[3] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
[4] Heminio Ometto Univ Ctr UNIARARAS, Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FASEB JOURNAL; v. 32, n. 1, p. 353-368, JAN 2018. |
| Citações Web of Science: | 9 |
| Resumo | |
In elderly persons, weak tendons contribute to functional limitations, injuries, and disability, but resistance training can attenuate this age-related decline. We evaluated the effects of resistance training on the extracellular matrix (ECM) of the calcaneal tendon (CT) in young and old rats and its effect on tendon remodeling. Wistar rats aged 3 mo (young, n = 30) and 20 mo (old, n = 30) were divided into 4 groups: young sedentary, young trained, old sedentary (OS), and old trained (OT). The training sessions were conducted over a 12-wk period. Aging in sedentary rats showed down-regulation in key genes that regulated ECMremodeling. Moreover, the OS group showed a calcification focus in the distal region of the CT, with reduced blood vessel volume density. In contrast, resistance training was effective in up-regulating connective tissue growth factor, VEGF, and decorin gene expression in old rats. Resistance training also increased proteoglycan content in young and old rats in special small leucine-rich proteoglycans and blood vessels and prevented calcification in OT rats. These findings confirm that resistance training is a potentialmechanismin the prevention of aging-related loss in ECMand that it attenuates the detrimental effects of aging in tendons, such as ruptures and tendinopathies. (AU) | |
| Processo FAPESP: | 10/19390-5 - Matriz extracelular no envelhecimento e suas adaptações ao treinamento de força no tendão calcâneo de ratos: abordagem molecular, celular e biomecânica. |
| Beneficiário: | Rita de Cássia Marqueti Durigan |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 11/11229-3 - Matriz extracelular no envelhecimento e suas adaptações ao treinamento de força no tendão calcâneo de ratos: abordagem molecular, celular e biomecânica |
| Beneficiário: | Heloisa Sobreiro Selistre de Araújo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/00798-2 - A matriz extracelular no envelhecimento, no exercício e no microambiente tumoral |
| Beneficiário: | Heloisa Sobreiro Selistre de Araújo |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |