Effects of aging and resistance training in rat tendon remodeling

Author(s)

Marqueti, Rita C. ^[1] ; Durigan, Joao L. Q. ^[1] ; Oliveira, Anderson Jose S. ^[1] ; Mekaro, Marcelo Shinyu ^[2] ; Guzzoni, Vinicius ^[2] ; Aro, Andrea A. ^[3] ; Pimentel, Edson Rosa ^{[3, 4]} ; Selistre-de-Araujo, Heloisa S. ^[2]

Affiliation

^[1] Univ Brasilia UnB, Campus Univ, Ctr Metropolitano 1, Conjunto A, BR-72220900 Brasilia, DF - Brazil

^[2] Fed Univ Sao Carlos UFSCar, Sao Carlos, SP - Brazil

^[3] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil

^[4] Heminio Ometto Univ Ctr UNIARARAS, Sao Paulo - Brazil

• Document type: Journal article
• Source: FASEB JOURNAL; v. 32, n. 1, p. 353-368, JAN 2018.
• Web of Science Citations: 9

Abstract

In elderly persons, weak tendons contribute to functional limitations, injuries, and disability, but resistance training can attenuate this age-related decline. We evaluated the effects of resistance training on the extracellular matrix (ECM) of the calcaneal tendon (CT) in young and old rats and its effect on tendon remodeling. Wistar rats aged 3 mo (young, n = 30) and 20 mo (old, n = 30) were divided into 4 groups: young sedentary, young trained, old sedentary (OS), and old trained (OT). The training sessions were conducted over a 12-wk period. Aging in sedentary rats showed down-regulation in key genes that regulated ECMremodeling. Moreover, the OS group showed a calcification focus in the distal region of the CT, with reduced blood vessel volume density. In contrast, resistance training was effective in up-regulating connective tissue growth factor, VEGF, and decorin gene expression in old rats. Resistance training also increased proteoglycan content in young and old rats in special small leucine-rich proteoglycans and blood vessels and prevented calcification in OT rats. These findings confirm that resistance training is a potentialmechanismin the prevention of aging-related loss in ECMand that it attenuates the detrimental effects of aging in tendons, such as ruptures and tendinopathies. (AU)

• FAPESP's process: 10/19390-5 - Aging-related alterations in extracellular matrix and its adaptations to strength training in Calcaneal tendon of rats: molecular, cellular, and biomechanical approach.
• Grantee: Rita de Cássia Marqueti Durigan
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/11229-3 - Aging-related alterations in extracellular matrix and its adaptations to strength training in calcaneal tendon of rats: molecular, cellular, and biomechanical approach
• Grantee: Heloisa Sobreiro Selistre de Araújo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/00798-2 - The extracellular matrix in aging, exercise and in the tumor microenvironment
• Grantee: Heloisa Sobreiro Selistre de Araújo
• Support Opportunities: Research Projects - Thematic Grants