| Texto completo | |
| Autor(es): |
Branco, Lucas M. T.
;
de Rezende, Thiago J. R.
;
Roversi, Caroline de O.
;
Zanao, Tamires
;
Casseb, Raphael F.
;
de Campos, Brunno M.
;
Franca, Jr., Marcondes C.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PSYCHIATRY RESEARCH-NEUROIMAGING; v. 272, p. 58-64, FEB 28 2018. |
| Citações Web of Science: | 3 |
| Resumo | |
We aimed to assess the brain signature of cognitive and behavioral impairment in C9orf72-negative non-demented ALS patients. The study included 50 amyotrophic lateral sclerosis (ALS) patients (out of 75 initially recruited) and 38 healthy controls. High-resolution T1-weighted and spin-echo diffusion tensor images were acquired in a 3 T MRI scanner. The multi atlas-based analysis protocol and the FreeSurfer tool were employed for gray matter assessment, and fiber tractography for white matter evaluation. Cognitively impaired ALS patients (n = 12) had bilateral amygdalae and left thalamic volumetric reduction compared to non-impaired ALS patients. Behaviorally impaired ALS patients (n = 14) had lower fractional anisotropy (FA) at the fornix in comparison with healthy subjects. These parameters did correlate with cognitive/behavioral scores, but not with motorfunctional parameters in the ALS cohort. We believe that basal ganglia and fornix damage might be related to cognitive and behavioral impairment across ALS-frontotemporal dementia continuum. Also, distinct anatomical areas seem to influence the behavioral and cognitive status of these individuals. (AU) | |
| Processo FAPESP: | 13/01766-7 - Contribuição ao diagnóstico, à fisiopatologia e à terapêutica das neuronopatias sensitivas |
| Beneficiário: | Marcondes Cavalcante Franca Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |