| Texto completo | |
| Autor(es): |
Bourgard, Catarina
[1]
;
Albrecht, Letusa
[1, 2]
;
Kayano, Ana C. A. V.
[1]
;
Sunnerhagen, Per
[3]
;
Costa, Fabio T. M.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Campinas UNICAMP, Dept Genet Evolut Microbiol & Immunol, Lab Trop Dis, Campinas, SP - Brazil
[2] Inst Carlos Chagas, Lab Regulat Gene Express, Curitiba, Parana - Brazil
[3] Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg - Sweden
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 8, FEB 8 2018. |
| Citações Web of Science: | 5 |
| Resumo | |
During the last decade, the vast omics field has revolutionized biological research, especially the genomics, transcriptomics and proteomics branches, as technological tools become available to the field researcher and allow difficult question-driven studies to be addressed. Parasitology has greatly benefited from next generation sequencing (NGS) projects, which have resulted in a broadened comprehension of basic parasite molecular biology, ecology and epidemiology. Malariology is one example where application of this technology has greatly contributed to a better understanding of Plasmodium spp. biology and host-parasite interactions. Among the several parasite species that cause human malaria, the neglected Plasmodium vivax presents great research challenges, as in vitro culturing is not yet feasible and functional assays are heavily limited. Therefore, there are gaps in our P. vivax biology knowledge that affect decisions for control policies aiming to eradicate vivax malaria in the near future. In this review, we provide a snapshot of key discoveries already achieved in P. vivax sequencing projects, focusing on developments, hurdles, and limitations currently faced by the research community, as well as perspectives on future vivax malaria research. (AU) | |
| Processo FAPESP: | 12/16525-2 - Plasmodium vivax: patogênese e infectividade |
| Beneficiário: | Fabio Trindade Maranhão Costa |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 13/20509-5 - Análise dos mecanismos imunopatológicos e moleculares envolvidos no processo de citoaderência de Plasmodium vivax |
| Beneficiário: | Catarina Baeta da Luz Bourgard |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |