Beta-defensin genes of the Colubridae snakes Phalotris mertensi, Thamnodynastes hypoconia, and T-strigatus

Autor(es)

de Oliveira, Yago Santana ^[1] ; Correa, Poliana G. ^[1] ; Oguiura, Nancy ^[1]

Afiliação do(s) autor(es)

^[1] Inst Butantan, Ecol & Evolut Lab, Ave Dr Vital Brasil 1500, BR-05503900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Toxicon; v. 146, p. 124-128, MAY 2018.
• Citações Web of Science: 0

Resumo

beta-Defensins are cationic antimicrobial peptides showing little sequence similarity but highly conserved tertiary structure stabilized by a six-cysteines-motif. Using a PCR approach, we described beta-defensin sequences with two exons in three species of Colubridae snakes with high sequence similarity between them. The deduced amino acid sequence presented the characteristics of beta-defensin family. The phylogenetic analysis using beta-defensin coding sequences of different snakes grouped them in two main branches: genes organized in three or two exons. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 15/00003-5 - Genes de toxinas de venenos e b-defensinas de serpentes
• Beneficiário: Nancy Oguiura
• Linha de fomento: Auxílio à Pesquisa - Regular