Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis

Autor(es)

Joaquim, Helena P. G. ^[1] ; Zanetti, Marcus V. ^{[2, 3, 1]} ; Serpa, Mauricio H. ^{[2, 3, 1]} ; Van de Bilt, Martinus T. ^[1] ; Sallet, Paulo C. ^[1] ; Chaim, Tiffany M. ^{[2, 3]} ; Busatto, Geraldo F. ^{[2, 3]} ; Gattaz, Wagner F. ^{[2, 1]} ; Talib, Leda L. ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept & Inst Psychiat, Lab Psychiat Neuroimaging, LIM 21, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCHIZOPHRENIA RESEARCH; v. 195, p. 402-405, MAY 2018.
• Citações Web of Science: 1

Resumo

Past studies have linked intracellular pathways related to psychotic disorders to the GSK3B enzyme. This study aimed to investigate GSK3B protein expression and phosphorylation in drug-naive first-episode psychosis patients (n = 43) at baseline and following symptom remission, and in healthy controls (n = 77). At baseline GSK3B total level was higher in patients (p < 0.001). In schizophrenia spectrum patients (n = 25) GSK3B total and phosphorylated levels were higher than in controls and patients with other non-affective psychotic disorders (n = 18) (p < 0.001; p = 0.027; p = 0.05 respectively). No enzyme changes were found after clinical remission. The implication of this finding for the biology of psychoses warrants further studies to clarify whether increased GSK3B may be useful as a biomarker for psychosis in general, and schizophrenia in particular. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/03905-4 - Avaliação de diferenças neurobiológicas entre pacientes com transtorno bipolar subtipos i e ii virgens de tratamento
• Beneficiário: Marcus Vinicius Zanetti
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/10350-9 - Proteômica da esquizofrenia: busca por biomarcadores em plaquetas
• Beneficiário: Helena Passarelli Giroud Joaquim Nadal
• Modalidade de apoio: Bolsas no Brasil - Doutorado