| Texto completo | |
| Autor(es): |
Joaquim, Helena P. G.
[1]
;
Zanetti, Marcus V.
[2, 3, 1]
;
Serpa, Mauricio H.
[2, 3, 1]
;
Van de Bilt, Martinus T.
[1]
;
Sallet, Paulo C.
[1]
;
Chaim, Tiffany M.
[2, 3]
;
Busatto, Geraldo F.
[2, 3]
;
Gattaz, Wagner F.
[2, 1]
;
Talib, Leda L.
[2, 1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept & Inst Psychiat, Lab Psychiat Neuroimaging, LIM 21, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCHIZOPHRENIA RESEARCH; v. 195, p. 402-405, MAY 2018. |
| Citações Web of Science: | 1 |
| Resumo | |
Past studies have linked intracellular pathways related to psychotic disorders to the GSK3B enzyme. This study aimed to investigate GSK3B protein expression and phosphorylation in drug-naive first-episode psychosis patients (n = 43) at baseline and following symptom remission, and in healthy controls (n = 77). At baseline GSK3B total level was higher in patients (p < 0.001). In schizophrenia spectrum patients (n = 25) GSK3B total and phosphorylated levels were higher than in controls and patients with other non-affective psychotic disorders (n = 18) (p < 0.001; p = 0.027; p = 0.05 respectively). No enzyme changes were found after clinical remission. The implication of this finding for the biology of psychoses warrants further studies to clarify whether increased GSK3B may be useful as a biomarker for psychosis in general, and schizophrenia in particular. (C) 2017 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 13/03905-4 - Avaliação de diferenças neurobiológicas entre pacientes com transtorno bipolar subtipos i e ii virgens de tratamento |
| Beneficiário: | Marcus Vinicius Zanetti |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/10350-9 - Proteômica da esquizofrenia: busca por biomarcadores em plaquetas |
| Beneficiário: | Helena Passarelli Giroud Joaquim |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |