Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis

Author(s)

Joaquim, Helena P. G. ^[1] ; Zanetti, Marcus V. ^{[2, 3, 1]} ; Serpa, Mauricio H. ^{[2, 3, 1]} ; Van de Bilt, Martinus T. ^[1] ; Sallet, Paulo C. ^[1] ; Chaim, Tiffany M. ^{[2, 3]} ; Busatto, Geraldo F. ^{[2, 3]} ; Gattaz, Wagner F. ^{[2, 1]} ; Talib, Leda L. ^{[2, 1]}

Affiliation

^[1] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept & Inst Psychiat, Lab Psychiat Neuroimaging, LIM 21, Sao Paulo - Brazil

• Document type: Journal article
• Source: SCHIZOPHRENIA RESEARCH; v. 195, p. 402-405, MAY 2018.
• Web of Science Citations: 1

Abstract

Past studies have linked intracellular pathways related to psychotic disorders to the GSK3B enzyme. This study aimed to investigate GSK3B protein expression and phosphorylation in drug-naive first-episode psychosis patients (n = 43) at baseline and following symptom remission, and in healthy controls (n = 77). At baseline GSK3B total level was higher in patients (p < 0.001). In schizophrenia spectrum patients (n = 25) GSK3B total and phosphorylated levels were higher than in controls and patients with other non-affective psychotic disorders (n = 18) (p < 0.001; p = 0.027; p = 0.05 respectively). No enzyme changes were found after clinical remission. The implication of this finding for the biology of psychoses warrants further studies to clarify whether increased GSK3B may be useful as a biomarker for psychosis in general, and schizophrenia in particular. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 13/03905-4 - NEUROBIOLOGICAL DIFFERENCES BETWEEN TREATMENT-NAIVE PATIENTS WITH BIPOLAR DISORDER SUBTYPES I AND II
• Grantee: Marcus Vinicius Zanetti
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/10350-9 - Proteomics of schizophrenia: the search for biomarkers in platelets
• Grantee: Helena Passarelli Giroud Joaquim Nadal
• Support Opportunities: Scholarships in Brazil - Doctorate