Serum, plasma and saliva biomarkers for head and neck cancer

Autor(es)

Rebolho Batista Arantes, Lidia Maria ^[1] ; De Carvalho, Ana Carolina ^[1] ; Melendez, Matias Eliseo ^[1] ; Carvalho, Andre Lopes ^[1]

Afiliação do(s) autor(es)

^[1] Barretos Canc Hosp, Mol Oncol Res Ctr, Rua Antenor Duarte Villela, 1331 Bairro Dr Paulo, BR-14784400 Barretos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS; v. 18, n. 1, p. 85-112, 2018.
• Citações Web of Science: 15

Resumo

Introduction: Head and neck squamous cell carcinoma (HNSCC) encompasses tumors arising from several locations (oral and nasal cavities, paranasal sinuses, salivary glands, pharynx, and larynx) and currently stands as the sixth most common cancer worldwide. The most important risk factors identified so far are tobacco and alcohol consumption, and, for a subgroup of HNSCCs, infection with high-risk types of human papillomavirus (HPV). Despite several improvements in the treatment of these tumors in the last decades, overall survival rates have only improved marginally, mainly due to the advanced clinical stage at diagnosis and the high rates of treatment failure associated with this late diagnosis. Areas covered: This review will focus on the feasibility of evaluating molecular-based biomarkers (mRNA, microRNA, lncRNA, DNA methylation and protein expression) in body fluids (serum, plasma, and saliva) as markers for diagnosis, prognosis, and surveillance. Expert commentary: The potential use of those markers in the clinical setting would allow for early diagnosis, prediction of treatment response, improvement in treatment selection and provide disease monitoring for early detection of tumor recurrence. It can ultimately be translated into better survival rates and improved quality of life for HNSCC patients. (AU)

• Processo FAPESP: 11/02864-7 - Alterações epigenéticas como biomarcadores em câncer de cabeça e pescoço
• Beneficiário: Lidia Maria Rebolho Batista Arantes
• Modalidade de apoio: Bolsas no Brasil - Doutorado