| Texto completo | |
| Autor(es): Mostrar menos - |
Almeida, Fausto
[1]
;
Wolf, Julie M.
[2]
;
da Silva, Thiago Aparecido
[3]
;
DeLeon-Rodriguez, Carlos M.
[2]
;
Rezende, Caroline Patini
[1]
;
Pessoni, Andre Moreira
[1]
;
Fernandes, Fabricio Freitas
[3]
;
Silva-Rocha, Rafael
[3]
;
Martinez, Roberto
[4]
;
Rodrigues, Marcio L.
[5, 6]
;
Roque-Barreira, Maria Cristina
[3]
;
Casadevall, Arturo
[7]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Yeshiva Univ, Dept Microbiol & Immunol, Albert Einstein Coll Med, New York, NY 10461 - USA
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cellular & Mol Biol, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Dept Internal Med, Ribeirao Preto Med Sch, BR-14048900 Ribeirao Preto, SP - Brazil
[5] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, BR-21941902 Rio De Janeiro - Brazil
[6] Fundacao Oswaldo Cruz Fiocruz, CDTS, BR-21041361 Rio De Janeiro - Brazil
[7] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 - USA
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURE COMMUNICATIONS; v. 8, DEC 6 2017. |
| Citações Web of Science: | 19 |
| Resumo | |
Cryptococcus neoformans is an encapsulated fungal pathogen that causes cryptococcosis, which is a major opportunistic infection in immunosuppressed individuals. Mammalian beta-galactoside-binding protein Galectin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during microbial infections including some fungal diseases. Here we show that this protein plays a role also in C. neoformans infection. We find augmented Gal-3 serum levels in human and experimental infections, as well as in spleen, lung, and brain tissues of infected mice. Gal-3-deficient mice are more susceptible to cryptococcosis than WT animals, as demonstrated by the higher fungal burden and lower animal survival. In vitro experiments show that Gal-3 inhibits fungal growth and exerts a direct lytic effect on C. neoformans extracellular vesicles (EVs). Our results indicate a direct role for Gal-3 in antifungal immunity whereby this molecule affects the outcome of C. neoformans infection by inhibiting fungal growth and reducing EV stability, which in turn could benefit the host. (AU) | |
| Processo FAPESP: | 16/03322-7 - Papel de galectina-3 na infecção por Cryptococcus neoformans |
| Beneficiário: | Fausto Bruno dos Reis Almeida |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 16/15055-3 - Papel de galectina-3 na infecção por Cryptococcus neoformans |
| Beneficiário: | Fausto Bruno dos Reis Almeida |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |