Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system

Autor(es)

Gomes, Clarissa P. C. ^[1] ; de Gonzalo-Calvo, David ^{[2, 3, 4]} ; Toro, Rocio ^{[5, 6]} ; Fernandes, Tiago ^{[7, 8]} ; Theisen, Daniel ^[9] ; Wang, Da-Zhi ^[8] ; Devaux, Yvan ^[1] ; Network, CardiolincTM

Afiliação do(s) autor(es)

^[1] Luxembourg Inst Hlth, Cardiovasc Res Unit, Luxembourg - Luxembourg

^[2] CSIC, Inst Biomed Res Barcelona IIBB, Barcelona - Spain

^[3] Biomed Res Inst Sant Pau IIB St Pau, Barcelona - Spain

^[4] Inst Hlth Carlos III, CIBERCV, Madrid - Spain

^[5] Univ Cadiz, Cadiz - Spain

^[6] Inst Biomed Res Cadiz INIBICA, Cadiz - Spain

^[7] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Biochem & Mol Biol Exercise, Sao Paulo - Brazil

^[8] Harvard Med Sch, Boston Childrens Hosp, Dept Cardiol, Boston, MA - USA

^[9] Luxembourg Inst Hlth, Sports Med Res Lab, Luxembourg - Luxembourg

• Tipo de documento: Artigo de Revisão
• Fonte: Clinical Science; v. 132, n. 9, p. 925-942, MAY 23 2018.
• Citações Web of Science: 3

Resumo

There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death worldwide. Despite the benefits of exercise, the intricacies of their underlying molecular mechanisms remain largely unknown. Non-coding RNAs (ncRNAs) have been recognized as a major regulatory network governing gene expression in several physiological processes and appeared as pivotal modulators in a myriad of cardiovascular processes under physiological and pathological conditions. However, little is known about ncRNA expression and role in response to exercise. Revealing the molecular components and mechanisms of the link between exercise and health outcomes will catalyse discoveries of new biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed. (AU)

• Processo FAPESP: 17/04899-9 - Investigação do mecanismo funcional e molecular da proteína ligante de RNA PCBP1 no coração
• Beneficiário: Tiago Fernandes
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado