Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases

Autor(es)

Machado de Rezende, Leandro Fornias ^[1] ; de Sa, Thiago Herick ^[2] ; Markozannes, Georgios ^[3] ; Rey-Lopez, Juan Pablo ^[4] ; Lee, I-Min ^{[5, 6]} ; Tsilidis, Konstantinos K. ^{[3, 7]} ; Ioannidis, John P. A. ^{[8, 9, 10, 11]} ; Eluf-Neto, Jose ^[1]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Nucleo Pesquisas Epidemiol Nutr & Saude, Sao Paulo - Brazil

^[3] Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina - Greece

^[4] Univ Sydney, Sydney Sch Publ Hlth, Prevent Res Collaborat, Sydney, NSW - Australia

^[5] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA

^[6] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA - USA

^[7] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London - England

^[8] Stanford Univ, Dept Stat, Sch Humanities & Sci, Stanford, CA 94305 - USA

^[9] Stanford Univ, Dept Med, Sch Med, Stanford Prevent Res Ctr, Stanford, CA 94305 - USA

^[10] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 - USA

^[11] Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA 94305 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: BRITISH JOURNAL OF SPORTS MEDICINE; v. 52, n. 13, p. 826-833, JUL 2018.
• Citações Web of Science: 23

Resumo

Objective To provide an overview of the breadth and validity of claimed associations between physical activity and risk of developing or dying from cancer. Design Umbrella review. Data sources We searched Medline, Embase, Cochrane Database and Web of Science. Eligibility criteria for selecting studies Systematic reviews about physical activity and cancer incidence and cancer mortality in different body sites among general population. Results We included 19 reviews covering 22 cancer sites, 26 exposure-outcome pairs metaanalyses and 541 original studies. Physical activity was associated with lower risk of seven cancer sites (colon, breast, endometrial, lung, oesophageal, pancreas and meningioma). Only colon (a protective association with recreational physical activity) and breast cancer (a protective association with overall physical activity) were supported by strong evidence and highly suggestive evidence, respectively. Evidence from endometrial, lung, oesophageal, pancreas and meningioma presented hints of uncertainty and bias in the literature (eg, not reaching P values < 10(-6)) showing large between-study heterogeneity and/or not demonstrating a definite direction for the effect when 95% prediction intervals were considered. Four of the 26 meta-analyses showed small study effects and 4 showed excess significance. Conclusion Physical activity is associated with a lower risk of several cancers, but only colon and breast cancer associations were supported by strong or highly suggestive evidence, respectively. Evidence from other cancer sites was less consistent, presenting hints of uncertainty and/or bias. (AU)

• Processo FAPESP: 14/25614-4 - Inatividade física e câncer: da avaliação da evidência etiológica ao impacto na saúde pública
• Beneficiário: Leandro Fórnias Machado de Rezende
• Modalidade de apoio: Bolsas no Brasil - Doutorado