Detection of different beta-lactamases encoding genes, including bla (NDM), and plasmid-mediated quinolone resistance genes in different water sources from Brazil

Autor(es)

Sanchez, Danilo Garcia ^[1] ; de Melo, Fernanda Maciel ^[1] ; Savazzi, Eduardo Angelino ^[2] ; Stehling, Eliana Guedes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] CETESB Companhia Ambiental Estado Sao Paulo, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ENVIRONMENTAL MONITORING AND ASSESSMENT; v. 190, n. 7 JUL 2018.
• Citações Web of Science: 3

Resumo

Bacterial resistance occurs by spontaneous mutations or horizontal gene transfer mediated by mobile genetic elements, which represents a great concern. Resistance to beta-lactam antibiotics is mainly due to the production of beta-lactamases, and an important mechanism of fluoroquinolone resistance is the acquisition plasmid determinants. The aim of this study was to verify the presence of beta-lactamase-encoding genes and plasmid-mediated quinolone resistance genes in different water samples obtained from So Paulo state, Brazil. A high level of these resistance genes was detected, being the bla (SHV), bla (GES), and qnr the most prevalent. Besides that, the bla (NDM) gene, which codify an important and hazardous metallo-beta-lactamase, was detected. (AU)

• Processo FAPESP: 15/18990-2 - Investigação dos mecanismos de resistência às quinolonas em isolados bacterianos ambientais
• Beneficiário: Eliana Guedes Stehling
• Modalidade de apoio: Auxílio à Pesquisa - Regular