Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Detection of different beta-lactamases encoding genes, including bla (NDM), and plasmid-mediated quinolone resistance genes in different water sources from Brazil

Full text
Author(s):
Sanchez, Danilo Garcia [1] ; de Melo, Fernanda Maciel [1] ; Savazzi, Eduardo Angelino [2] ; Stehling, Eliana Guedes [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[2] CETESB Companhia Ambiental Estado Sao Paulo, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ENVIRONMENTAL MONITORING AND ASSESSMENT; v. 190, n. 7 JUL 2018.
Web of Science Citations: 3
Abstract

Bacterial resistance occurs by spontaneous mutations or horizontal gene transfer mediated by mobile genetic elements, which represents a great concern. Resistance to beta-lactam antibiotics is mainly due to the production of beta-lactamases, and an important mechanism of fluoroquinolone resistance is the acquisition plasmid determinants. The aim of this study was to verify the presence of beta-lactamase-encoding genes and plasmid-mediated quinolone resistance genes in different water samples obtained from So Paulo state, Brazil. A high level of these resistance genes was detected, being the bla (SHV), bla (GES), and qnr the most prevalent. Besides that, the bla (NDM) gene, which codify an important and hazardous metallo-beta-lactamase, was detected. (AU)

FAPESP's process: 15/18990-2 - Investigation of quinolone resistance mechanisms in environmental bacterial isolates
Grantee:Eliana Guedes Stehling
Support Opportunities: Regular Research Grants