| Texto completo | |
| Autor(es): |
Francis-Oliveira, Jose
[1]
;
Vilar Higa, Guilherme S.
[1]
;
Munhoz Dati, Livia Mendonca
[1]
;
Shieh, Iane Carvalho
[1]
;
De Pasquale, Roberto
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Fisiol & Biofis, ACidade Univ, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF NEUROSCIENCE; v. 38, n. 25, p. 5649-5665, JUN 20 2018. |
| Citações Web of Science: | 2 |
| Resumo | |
Metaplasticity is the regulation of synaptic plasticity based on the history of previous synaptic activation. This concept was formulated after observing that synaptic changes in the visual cortex are not fixed, but dynamic and dependent on the history of visual information flux. In visual cortical neurons, sustained synaptic stimulation activate the enzymatic complex NOX2, resulting in the generation of reactive oxygen species (ROS). NOX2 is the main molecular structure responsible for translating neural activity into redox modulation of intracellular signaling pathways involved in plastic changes. Here, we studied the interaction between NOX2 and visual experience as metaplastic factors regulating synaptic plasticity at the supergranular layers of the mouse visual cortex. We found that genetic inhibition of NOX2 reverses the polarizing effects of dark rearing from LTP to LTD. In addition, we demonstrate that this process relies on changes in the NMDA receptor functioning. Altogether, this work indicates a role of ROS in the activity-dependent regulation of cortical synaptic plasticity. (AU) | |
| Processo FAPESP: | 11/23874-0 - Estresse oxidativo e plasticidade sináptica no córtex visual primário |
| Beneficiário: | Roberto De Pasquale |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 12/07522-0 - Estresse oxidativo e plasticidade sináptica no córtex visual primário |
| Beneficiário: | Roberto De Pasquale |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |