Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Blood lead and cadmium levels in preschool children and associated risk factors in Sao Paulo, Brazil

Texto completo
Autor(es):
Kaneshiro Olympio, Kelly Polido [1] ; da Rocha Silva, Julia Prestes [1] ; da Silva, Agnes Soares [2] ; de Oliveira Souza, Vanessa Cristina [3] ; Rabelo Buzalaf, Marilia Afonso [4] ; Barbosa, Jr., Fernando [3] ; Alves Cardoso, Maria Regina [5]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Saude Publ, Dept Saude Ambiental, Sao Paulo, SP - Brazil
[2] Pan Amer Hlth Org, PAHO WHO, Communicable Dis & Environm Determinants Hlth CDE, Washington, DC - USA
[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Fac Odontol Bauru, Dept Ciencias Biol, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Environmental Pollution; v. 240, p. 831-838, SEP 2018.
Citações Web of Science: 7
Resumo

In Brazil, there are scarce data on lead (Pb) and cadmium (Cd) contamination, especially for more vulnerable populations such as preschool children. In this paper, we answer two questions: (1) What are the exposure levels of lead and cadmium in preschool children, in Sao Paulo, Brazil? and (2) What are the risk factors associated with this exposure? This cross-sectional study included 50 day care centers (DCCs), totaling 2463 children aged 1-4 years. Venous blood samples were analyzed by ICP-MS. Questionnaires were administered to the parents. Multiple logistic regression models were used to identify associations between blood lead levels (BLLs) and blood cadmium levels (BCLs) and potential risk factors. The geometric mean for BLLs was 2.16 mu g/dL (95% CI: 2.10-2.22 mu g/dL), and the 97.5th percentile was 13.9 mu g/dL (95% CI: 10.0-17.3 mu g/dL). For cadmium exposure, the geometric mean for BCLs was 0.48 a (95% CI: 0.47-0.50 mu g/L), and the 95th percentile was 2.57 mu g/L (95% CI: 2.26-2.75 mu g/L). The DCCs' geographic region was associated with high BLLs and BCLs, indicating hot spots for lead and cadmium exposures. In addition, it was found that the higher the vehicles flow, the higher were the BLLs in children. Red lead in household gates was also an important risk factor for lead exposure. Comparing these results with the findings of the Fourth National Report on Human Exposure to Environmental Chemicals by CDC-2013, it was found that in Brazilian preschool children the BLLs are almost three times higher (97.5th percentile) and the BCLs are almost twelve times higher (95th percentile) than those in U.S. children. This information is essential to formulate public health policies. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 11/23272-0 - Exposição a chumbo em São Paulo: níveis sanguíneos em pré-escolares e fatores de risco associados
Beneficiário:Maria Regina Alves Cardoso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/21840-4 - Exposição a metais não essenciais em São Paulo: níveis sanguíneos em pré-escolares e fatores de risco associados
Beneficiário:Maria Regina Alves Cardoso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/13076-0 - Exposição a chumbo em São Paulo: níveis sanguíneos em pré-escolares e fatores de risco associados
Beneficiário:Kelly Polido Kaneshiro Olympio
Linha de fomento: Bolsas no Brasil - Pós-Doutorado