Acrocomia aculeata oil: Beneficial effects on cyclophosphamide-induced reproductive toxicity in male rats

Autor(es)

Arena, A. C. ^[1] ; Jorge, B. C. ^[1] ; Silva, M. C. ^[1] ; de Barros, A. L. ^[1] ; Fernandes, A. A. H. ^[2] ; Nobrega, R. H. ^[1] ; Martinez, E. R. M. ^[1] ; Cardoso, C. A. L. ^[3] ; Anselmo-Franci, J. A. ^[4] ; Muzzi, R. M. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Inst Biosci Botucatu, Dept Morphol, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista, Inst Biosci Botucatu, Dept Chem & Biochem, Botucatu, SP - Brazil

^[3] Mato Grosso do Sul State Univ, Dourados, MS - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto, SP - Brazil

^[5] Fed Univ Grande Dourados, Dourados, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANDROLOGIA; v. 50, n. 6 AUG 2018.
• Citações Web of Science: 2

Resumo

This study aimed to evaluate the effects of the extracted oil of Acrocomia aculeata pulp in preventing or mitigating the reproductive toxicity induced by cyclophosphamide (CP) in male rats. Adult male rats were segregated into seven groups that received vehicle, 100mg/kg/day of CP, or 10mg/kg/day of -carotene or 3 or 30mg/kg/day of A.aculeata oil co-administered with CP. A.aculeata oil exhibited a high content of -carotene. CP treatment induced reproductive toxicity in the animals, as it changed the reproductive organs weight, hormone levels, sperm counts and testicular histology. In contrast, co-administration of A.aculeata improved CP-induced alterations in these parameters. A.aculeata oil also increased the gene Ckit expression and normalised the antioxidant enzymes levels which were changed by CP. The A.aculeata oil is capable of protecting the male reproductive system from the adverse effects of CP, possibly by acting as an antioxidant and increasing the Ckit gene expression. (AU)

• Processo FAPESP: 13/01802-3 - Avaliação dos efeitos do óleo extraído de Acrocomia aculeata sobre a toxicidade reprodutiva induzida por ciclofosfamida em ratos machos
• Beneficiário: Arielle Cristina Arena
• Modalidade de apoio: Auxílio à Pesquisa - Regular