Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus

Autor(es):Mostrar menos -

Campanella, Nathalia C. ^[1] ; Lacerda, Croider Franco ^{[1, 2]} ; Berardinelli, Gustavo Noriz ^[1] ; Abrahao-Machado, Lucas Faria ^[3] ; Cruvinel-Carloni, Adriana ^[1] ; Torres de Oliveira, Antoonio Talvane ^[2] ; Scapulatempo-Neto, Cristovam ^{[1, 3]} ; Crema, Eduardo ^[4] ; Adad, Sheila Jorge ^[4] ; Marchesan Rodrigues, Maria Aparecida ^[5] ; Coelho Arruda Henry, Maria Aparecida ^[5] ; Guimaraes, Denise Peixoto ^{[6, 1]} ; Reis, Rui Manuel ^{[7, 8, 1]}

Afiliação do(s) autor(es)

^[1] Barretos Canc Hosp, Mol Oncol Res Ctr, Sao Paulo - Brazil

^[2] Barretos Canc Hosp, Dept Digest Surg, Sao Paulo - Brazil

^[3] Barretos Canc Hosp, Dept Pathol & Mol Diagnost, Sao Paulo - Brazil

^[4] Univ Fed Triangulo Mineiro, Med Sch, Dept Digest Surg & Pathol, Uberaba, MG - Brazil

^[5] UNESP Sao Paulo State Univ, Med Sch, Dept Gastroenterol Surg & Pathol, Botucatu, SP - Brazil

^[6] Barretos Canc Hosp, Dept Endoscopy, Sao Paulo - Brazil

^[7] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga - Portugal

^[8] ICVS 3Bs PT Govt Associate Lab, Braga - Portugal

• Tipo de documento: Artigo Científico
• Fonte: BIOMARKERS IN MEDICINE; v. 12, n. 6, p. 573-582, JUN 2018.
• Citações Web of Science: 1

Resumo

Aim: The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM). Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out of 35 ESCC cases showed MSI-L (11.4%) and only one out of 26 CM cases presented MSI-L (3.9%). The MSI-H was observed in an ESCC/CM patient that presents lack of MSH6 immunostaining corroborating deficiency in MMR pathway. Interestingly, the MSI-H ESCC/CM case also presented a deletion the HSP110 poly(T) 17 gene. Discussion/conclusion: Taking together, we concluded that MSI is a rare event in esophageal squamous cell carcinoma, but can be associated with CM. (AU)

• Processo FAPESP: 16/03634-9 - Explorando a importância biológica da Raf Kinase inhibitor (RKIP) nos tumores estromais gastrointestinais (GIST).
• Beneficiário: Nathália Cristina Campanella
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado