| Texto completo | |
| Autor(es): |
da Silva, Amanda F.
[1]
;
Fernandes, Alessandra A. G.
[1]
;
Thurow, Samuel
[1]
;
Stivanin, Mateus L.
[1]
;
Jurberg, Igor D.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Inst Chem, Rua Monteiro Lobato 270, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | SYNTHESIS-STUTTGART; v. 50, n. 13, p. 2473-2489, JUL 2018. |
| Citações Web of Science: | 11 |
| Resumo | |
Isoxazol-5-one rings have been identified as relevant motifs in drug candidates, agrochemicals, and materials. Furthermore, this heterocycle has been also applied as a versatile building block for the preparation of a variety of densely functionalized molecules. This short review will present the most representative applications of isoxazol-5-ones in organic synthesis while discussing their properties and reactivity. 1 Introduction 1.1 General Aspects 1.1.1 Tautomerism 1.1.2 Importance: Natural Products Isolation, Biological Activity, and Materials 1.1.3 Preparation Methods 2 Isoxazol-5-ones in Organic Synthesis 2.1 General Reactivity 2.2 Specific Examples 2.2.1 Alkylation Strategies 2.2.2 Alkyne Synthesis 2.2.3 Annulation Reactions 2.2.4 N-O Bond Insertions 2.2.4.1 Preparation of 1,3-Oxazin-6-ones 3 Conclusions (AU) | |
| Processo FAPESP: | 17/24017-0 - Aplicação de Isoxazolonas em Síntese Orgânica |
| Beneficiário: | Igor Dias Jurberg |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |