| Full text | |
| Author(s): |
da Silva, Amanda F.
[1]
;
Fernandes, Alessandra A. G.
[1]
;
Thurow, Samuel
[1]
;
Stivanin, Mateus L.
[1]
;
Jurberg, Igor D.
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Chem, Rua Monteiro Lobato 270, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
|
| Document type: | Review article |
| Source: | SYNTHESIS-STUTTGART; v. 50, n. 13, p. 2473-2489, JUL 2018. |
| Web of Science Citations: | 11 |
| Abstract | |
Isoxazol-5-one rings have been identified as relevant motifs in drug candidates, agrochemicals, and materials. Furthermore, this heterocycle has been also applied as a versatile building block for the preparation of a variety of densely functionalized molecules. This short review will present the most representative applications of isoxazol-5-ones in organic synthesis while discussing their properties and reactivity. 1 Introduction 1.1 General Aspects 1.1.1 Tautomerism 1.1.2 Importance: Natural Products Isolation, Biological Activity, and Materials 1.1.3 Preparation Methods 2 Isoxazol-5-ones in Organic Synthesis 2.1 General Reactivity 2.2 Specific Examples 2.2.1 Alkylation Strategies 2.2.2 Alkyne Synthesis 2.2.3 Annulation Reactions 2.2.4 N-O Bond Insertions 2.2.4.1 Preparation of 1,3-Oxazin-6-ones 3 Conclusions (AU) | |
| FAPESP's process: | 17/24017-0 - Application of Isoxazolones in Organic Synthesis |
| Grantee: | Igor Dias Jurberg |
| Support Opportunities: | Regular Research Grants |