| Grant number: | 17/24017-0 |
| Support type: | Regular Research Grants |
| Duration: | February 01, 2018 - January 31, 2020 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Principal researcher: | Igor Dias Jurberg |
| Grantee: | Igor Dias Jurberg |
| Home Institution: | Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract
This project aims to study a series of transformations involving isoxazol-5-ones within the context of organocatalysis, as well as metal catalysis. Specifically, the following transformations will be studied: organocatalyzed 1,2-additions to 4-substituted isoxazol-5-ones aiming at the preparationof beta-aminoacid derivatives, the use of dienamines derived from alkylidene isoxazolones and pyrazolones aiming at their functionalization and the development of cascade reactions, the decarboxylation of isoxazolones and their trapping with nucleophiles, the preparation of functionalized indoles, pyridines, isoxazoles and the generation of benzyne and their further transformations. All these projects have the goal of extending the chemistry of isoxazol-5-ones, in order to demonstrate their versatility in organic synthesis. As a consequence, we aim to establish this class of compounds as a powerful source for a variety of functional groups and reactivity patterns that can be accessed, thus contributing to the development of new catalytic technologies. (AU)
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