Insights into Protein-Ionic Liquid Interactions Aiming at Macromolecule Delivery Systems

Autor(es)

Harada, Liliam K. ^[1] ; Pereira, Jorge F. B. ^[2] ; Campos, Welida F. ^[1] ; Silva, Erica C. ^[1] ; Moutinho, Carla G. ^[3] ; Vila, Marta M. D. C. ^[1] ; Oliveira, Jr., Jose M. ^[1] ; Teixeira, Jose A. ^[4] ; Balcao, Victor M. ^{[1, 4]} ; Tubino, Matthieu ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sorocaba, Lab Biofilmes & Bacteriofagos PhageLab, Grp Pesquisa Intelligent Biosensing & Biomol Stab, BR-18023000 Sorocaba, SP - Brazil

^[2] Univ Estadual Paulista Unesp, Fac Ciencias Farmaceut, Dept Bioproc & Biotecnol, BR-14800901 Araraquara, SP - Brazil

^[3] Univ Fernando Pessoa, Energy Environm & Hlth Res Unit FP ENAS, P-4249004 Porto - Portugal

^[4] Univ Minho, Ctr Biol Engn CEB, P-4710057 Braga - Portugal

^[5] Univ Estadual Campinas Unicamp, Inst Quim, BR-13083097 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of the Brazilian Chemical Society; v. 29, n. 10, p. 1983-1998, OCT 2018.
• Citações Web of Science: 4

Resumo

Over the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio) pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper. (AU)

• Processo FAPESP: 16/08884-3 - PneumoPhageColor - desenvolvimento de um kit de biodetecção colorimétrica de Pseudomonas aeruginosa com base em partículas fágicas
• Beneficiário: Vitor Manuel Cardoso Figueiredo Balcão
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/12234-4 - TransAppIL - permeação cutânea de entidades proteicas estabilizadas estruturalmente e funcionalmente, carreadas por líquidos iônicos
• Beneficiário: Marta Maria Duarte Carvalho Vila
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/16641-3 - Estabilização estrutural e funcional de sericina em hidrogel biopolissacarídico: bio-origami para a regeneração de pele
• Beneficiário: Liliam Katsue Harada Rocha
• Linha de fomento: Bolsas no Brasil - Mestrado