Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insights into Protein-Ionic Liquid Interactions Aiming at Macromolecule Delivery Systems

Full text
Author(s):
Harada, Liliam K. [1] ; Pereira, Jorge F. B. [2] ; Campos, Welida F. [1] ; Silva, Erica C. [1] ; Moutinho, Carla G. [3] ; Vila, Marta M. D. C. [1] ; Oliveira, Jr., Jose M. [1] ; Teixeira, Jose A. [4] ; Balcao, Victor M. [1, 4] ; Tubino, Matthieu [5]
Total Authors: 10
Affiliation:
[1] Univ Sorocaba, Lab Biofilmes & Bacteriofagos PhageLab, Grp Pesquisa Intelligent Biosensing & Biomol Stab, BR-18023000 Sorocaba, SP - Brazil
[2] Univ Estadual Paulista Unesp, Fac Ciencias Farmaceut, Dept Bioproc & Biotecnol, BR-14800901 Araraquara, SP - Brazil
[3] Univ Fernando Pessoa, Energy Environm & Hlth Res Unit FP ENAS, P-4249004 Porto - Portugal
[4] Univ Minho, Ctr Biol Engn CEB, P-4710057 Braga - Portugal
[5] Univ Estadual Campinas Unicamp, Inst Quim, BR-13083097 Campinas, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 29, n. 10, p. 1983-1998, OCT 2018.
Web of Science Citations: 4
Abstract

Over the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper. (AU)

FAPESP's process: 16/16641-3 - Structural and functional stabilization of sericin in a biopolysaccharide hydrogel: bio-origami for skin regeneration
Grantee:Liliam Katsue Harada Rocha
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/12234-4 - TransAppIL - Transdermal delivery of structurally and functionally stabilized protein entities applying ionic liquids.
Grantee:Marta Maria Duarte Carvalho Vila
Support Opportunities: Regular Research Grants
FAPESP's process: 16/08884-3 - PneumoPhageColor - development of a colorimetric biodetection kit for Pseudomonas aeruginosa based on phage particles
Grantee:Vitor Manuel Cardoso Figueiredo Balcão
Support Opportunities: Regular Research Grants