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Physicochemical and structural properties of ionic liquids and drugs interacting with biologicaly relevant systems

Grant number: 15/15822-1
Support type:Regular Research Grants
Duration: December 01, 2015 - November 30, 2017
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Leandro Ramos Souza Barbosa
Grantee:Leandro Ramos Souza Barbosa
Home Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

This research project is divided into two parts; the first one will be centered in the study of the influence of ionic liquids (ILs) in biomimetic membrane systems and also in model proteins, whereas the second part (which will be developed concomitantly with the first), will be focused in the influence of drugs in the structure of liposomes (vesicles) used as carriers in different areas of health, with particular attention to leishmaniasis, the well-known Drug-delivery systems. The ILs, has attracted great attention from both the academic world, as well as the industrial one, due to its numerous applications. ILs are salts composed of an organic ion and a counter-ion that could be organic or inorganic and whose melting temperature is below 100 ° C, which means that these salts are in the liquid state at room temperature. Much of the interest in the study of ionic liquids is due to their low toxicity indicated by a low volatility. However little is known about their interaction with biological relevant systems such as proteins and lipid membranes. In this context we will study the influence of different ILs have the structure and function of proteins and model lipid membranes. In parallel we will also study the physicochemical changes induced by encapsulation of hydrophobic drugs in liposomes systems with the drug delivery purpose. These systems have vectoring capability, increased drug stability and the possibility of encapsulation of hydrophilic and lipophilic drugs inside. In particular we are interested in encapsulating drugs with potential use against negligible tropical diseases such as leishmaniasis. This stage of the project will be held in collaboration with prof. Dr. André Tempone, the Adolfo Lutz Institute, FMUSP. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FEITOSA, VALKER ARAUJO; DE ALMEIDA, VINICIUS CORDEIRO; MALHEIROS, BARBARA; DE CASTRO, RAPHAEL DIAS; SOUZA BARBOSA, LEANDRO RAMOS; PEREIRA CERIZE, NATALIA NETO; RANGEL-YAGUI, CARLOTA DE OLIVEIRA. Polymeric micelles of pluronic F127 reduce hemolytic potential of amphiphilic drugs. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 180, p. 177-185, AUG 1 2019. Web of Science Citations: 0.
TIROLI-CEPEDA, ANA O.; SERAPHIM, THIAGO V.; PINHEIRO, GLAUCIA M. S.; SOUTO, DENIO E. P.; KUBOTA, LAURO T.; BORGES, JULIO C.; BARBOSA, LEANDRO R. S.; RAMOS, CARLOS H. I. Studies on the effect of the J-domain on the substrate binding domain (SBD) of Hsp70 using a chimeric human J-SBD polypeptide. International Journal of Biological Macromolecules, v. 124, p. 111-120, MAR 1 2019. Web of Science Citations: 0.
ADAO, REGINA; ZANPHORLIN, LETICIA M.; LIMA, TATIANI B.; SRIRANGANADANE, DEV; DAHLSTROM, KATHE M.; PINHEIRO, GLAUCIA M. S.; GOZZO, FABIO C.; BARBOSA, LEANDRO R. S.; RAMOS, CARLOS H. I. Revealing the interaction mode of the highly flexible Sorghum bicolor Hsp70/Hsp90 organizing protein (Hop): A conserved carboxylate clamp confers high affinity binding to Hsp90. JOURNAL OF PROTEOMICS, v. 191, n. SI, p. 191-201, JAN 16 2019. Web of Science Citations: 0.
CARDUCCI, FEDERICA; CASADEI, BRUNA RENATA; MARIANI, PAOLO; BARBOSA, LEANDRO RAMOS SOUZA. X-Ray Characterization of Pharmaceutical and Cosmetic Lipidic Nanoparticles for Cutaneous Application. CURRENT PHARMACEUTICAL DESIGN, v. 25, n. 21, p. 2364-2374, 2019. Web of Science Citations: 1.
WONG, KEITH S.; MABANGLO, MARK F.; SERAPHIM, THIAGO V.; MOLLICA, ANTONIO; MAO, YU-QIAN; RIZZOLO, KAMRAN; LEUNG, ELISA; MOUTAOUFIK, MOHAMED T.; HOELL, LARISSA; PHANSE, SADHNA; GOODREID, JORDAN; BARBOSA, LEANDRO R. S.; RAMOS, CARLOS H. I.; BABU, MOHAN; MENNELLA, VITO; BATEY, ROBERT A.; SCHIMMER, AARON D.; HOURY, WALID A. Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death. Cell Chemical Biology, v. 25, n. 8, p. 1017+, AUG 16 2018. Web of Science Citations: 6.
SILVA, NOELI S. M.; SERAPHIM, THIAGO V.; MINARI, KARINE; BARBOSA, LEANDRO R. S.; BORGES, JULIO C. Comparative studies of the low-resolution structure of two p23 co-chaperones for Hsp90 identified in Plasmodium falciparum genome. International Journal of Biological Macromolecules, v. 108, p. 193-204, MAR 2018. Web of Science Citations: 2.
DA COSTA-SILVA, THAIS ALVES; GALISTEO, JR., ANDRES JIMENEZ; LAULETTA LINDOSO, JOSE ANGELO; BARBOSA, LEANDRO R. S.; TEMPONE, ANDRE GUSTAVO. Nanoliposomal Buparvaquone Immunomodulates Leishmania infantum-Infected Macrophages and Is Highly Effective in a Murine Model. Antimicrobial Agents and Chemotherapy, v. 61, n. 4 APR 2017. Web of Science Citations: 6.

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