| Texto completo | |
| Autor(es): |
Sorgi, Carlos Arterio
[1]
;
Ferranti Peti, Ana Paula
[1]
;
Petta, Tania
[1]
;
Galvao Meirelles, Alyne Favero
[1]
;
Fontanari, Caroline
[1]
;
Beraldo de Moraes, Luiz Alberto
[2]
;
Faccioli, Lucia Helena
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Av Bandeirantes 3900, BR-14049901 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC DATA; v. 5, AUG 21 2018. |
| Citações Web of Science: | 2 |
| Resumo | |
Eicosanoids comprise a class of bioactive lipids derived from a unique group of essential fatty acids that mediate a variety of important physiological functions. Owing to the structural diversity of these lipids, their analysis in biological samples is often a major challenge. Advancements in mass spectrometric have been helpful for the characterization and quantification of these molecular lipid species in complex matrices. However, there are technical limitations to this approach, including low-abundant and/or poorly ionizable lipids. Using high-resolution multiple-reaction monitoring (MRMHR), we were able to develop a targeted bioanalytical method for eicosanoid quantification. For this, we optimized the LC-MS/MS conditions and evaluated several parameters, including linearity, limits of quantification, matrix effects and recovery yields. For validation purposes, we looked at the method's precision and accuracy. A library of high-resolution fragmentation spectra for eicosanoids was developed. Our comprehensive dataset meets benchmark standards for targeted analysis, having been derived using best-practice workflows and rigorous quality assessments. As such, our method has applications for determining complex eicosanoid profiles in the biomedical field. (AU) | |
| Processo FAPESP: | 14/07125-6 - Novos aspectos funcionais dos eicosanóides |
| Beneficiário: | Lúcia Helena Faccioli |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 16/16788-4 - Identificação e quantificação simultânea de eicosanóides derivados da via do citocromo-P450 (CYP450) utilizando a cromatografia líquida de alta eficiência acoplada à espectrometria de massas sequencial (HPLC-MS/MS) |
| Beneficiário: | Ana Paula Ferranti Peti |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 15/00658-1 - Novos aspectos funcionais dos eicosanóides |
| Beneficiário: | Lúcia Helena Faccioli |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |