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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil

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Autor(es):
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de Campos, Tatiana Amabile [1] ; Goncalves, Laura Fernandes [1] ; Magalhaes, Kelly Grace [1] ; Martins, Vicente de Paulo [1] ; Pappas Junior, Georgios Joannis [1] ; Peirano, Gisele [2] ; Pitout, Johann D. D. [2] ; Goncalves, Guilherme Bartolomeu [3] ; Rueda Furlan, Joao Pedro [3] ; Stehling, Eliana Guedes [3] ; Pitondo-Silva, Andre [4]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Brasilia, Inst Biol Sci, Dept Cell Biol, Brasilia, DF - Brazil
[2] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB - Canada
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto - Brazil
[4] Univ Ribeirao Preto, Sch Dent, Ribeirao Preto - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN MEDICINE; v. 5, SEP 21 2018.
Citações Web of Science: 1
Resumo

We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60-70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed invasion and toxicity to epithelial Hep-2 cells; resistance to cell microbicidal mechanisms; and blood and human serum survival, evidencing their pathogenic potential. This study highlights the risk of infection caused by hmKp strains not characterized as hvKP as well as the clinical implications and difficulty of treatment, especially in elderly or immunocompromised patients. (AU)

Processo FAPESP: 13/22581-5 - Estudo dos mecanismos de patogenicidade e correlação com resistência a antimicrobianos de Klebsiella pneumoniae isoladas no Brasil e em países dos cinco continentes
Beneficiário:André Pitondo da Silva
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores