Tetracycline@silverions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration

Autor(es)

Bouchmella, Karim ^{[1, 2, 3]} ; Campanaro, Felipe Davi ^{[1, 2]} ; Mondo, Gabriela Borba ^{[1, 2, 3]} ; Santos, Murilo Izidoro ^[2] ; Franco, Caio Haddad ^[4] ; Moraes, Carolina Borsoi ^[4] ; Biolley, Christine ^[5] ; Mehdi, Ahmad ^[5] ; Cardoso, Mateus Borba ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] CNPEM, Lab Nacl Nanotecnol LNNano, BR-13083970 Campinas, SP - Brazil

^[2] CNPEM, LNLS, BR-13083970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas UNICAMP, IQ, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil

^[4] CNPEM, Lab Nacl Biociencias LNBio, BR-13083970 Campinas, SP - Brazil

^[5] Univ Montpellier, CNRS, UMR5253, ICGM, ENSCM, F-34095 Montpellier - France

• Tipo de documento: Artigo Científico
• Fonte: Nanomedicine; v. 13, n. 14, p. 1731-1751, JUL 2018.
• Citações Web of Science: 2

Resumo

Aim: Polyether pores were designed and tetracycline-loaded mesoporous silica materials, with their surface decorated by silver ions, were prepared, with the aim of reaching high antibacterial activity. Meanwhile, mammalian cell cytotoxicity and hemolytic effects were not observed using material concentrations tenfold the ones optimized for the bactericidal tests. Methods: Pore size was tuned by changing the polyether content and the surface was covalently decorated with silver thiolate groups. Results: We showed that the biological activity was enhanced by modulating silver ions and tetracycline releases by tuning silver thiolate group concentration on the silica surface and/or by modulating the pH of the environment. Conclusion: The combined use of tetracycline and silver ions with the mesoporous drug-delivery carrier was a very effective strategy against susceptible and tetracycline-resistant Escherichia coli bacteria. (AU)

• Processo FAPESP: 14/22322-2 - Funcionalização de nanopartículas de sílica: aumentando a interação biológica
• Beneficiário: Mateus Borba Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/25406-5 - Organizando a matéria: colóides formados por associação de surfactantes, polímeros e nanopartículas
• Beneficiário: Watson Loh
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/16905-0 - Estabilidade coloidal e coroa de proteínas: aspectos fundamentais para a manutenção das propriedades de nanopartículas de sílica em meios biológicos
• Beneficiário: Gabriela Borba Mondo
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto