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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tetracycline@silverions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration

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Bouchmella, Karim [1, 2, 3] ; Campanaro, Felipe Davi [1, 2] ; Mondo, Gabriela Borba [1, 2, 3] ; Santos, Murilo Izidoro [2] ; Franco, Caio Haddad [4] ; Moraes, Carolina Borsoi [4] ; Biolley, Christine [5] ; Mehdi, Ahmad [5] ; Cardoso, Mateus Borba [1, 2, 3]
Total Authors: 9
[1] CNPEM, Lab Nacl Nanotecnol LNNano, BR-13083970 Campinas, SP - Brazil
[2] CNPEM, LNLS, BR-13083970 Campinas, SP - Brazil
[3] Univ Estadual Campinas UNICAMP, IQ, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil
[4] CNPEM, Lab Nacl Biociencias LNBio, BR-13083970 Campinas, SP - Brazil
[5] Univ Montpellier, CNRS, UMR5253, ICGM, ENSCM, F-34095 Montpellier - France
Total Affiliations: 5
Document type: Journal article
Source: Nanomedicine; v. 13, n. 14, p. 1731-1751, JUL 2018.
Web of Science Citations: 1

Aim: Polyether pores were designed and tetracycline-loaded mesoporous silica materials, with their surface decorated by silver ions, were prepared, with the aim of reaching high antibacterial activity. Meanwhile, mammalian cell cytotoxicity and hemolytic effects were not observed using material concentrations tenfold the ones optimized for the bactericidal tests. Methods: Pore size was tuned by changing the polyether content and the surface was covalently decorated with silver thiolate groups. Results: We showed that the biological activity was enhanced by modulating silver ions and tetracycline releases by tuning silver thiolate group concentration on the silica surface and/or by modulating the pH of the environment. Conclusion: The combined use of tetracycline and silver ions with the mesoporous drug-delivery carrier was a very effective strategy against susceptible and tetracycline-resistant Escherichia coli bacteria. (AU)

FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
Grantee:Mateus Borba Cardoso
Support type: Regular Research Grants
FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/16905-0 - Correlation between the protein corona and biological activity of silica nanoparticles
Grantee:Gabriela Borba Mondo
Support type: Scholarships in Brazil - Doctorate (Direct)