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Functionalization of silica nanoparticles: increasing biological interaction

Grant number: 14/22322-2
Support type:Regular Research Grants
Duration: March 01, 2015 - May 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Mateus Borba Cardoso
Grantee:Mateus Borba Cardoso
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Campinas, SP, Brazil
Assoc. researchers: Bouchmella Karim ; Carlos Sato Baraldi Dias ; Jörg Kobarg ; Juliana Martins de Souza e Silva ; Marcio Chaim Bajgelman


The proposal described here aims to surface functionalization of mesoporous silica nanoparticles (NSMs) in order to increase the biological effectiveness and reduce the cytotoxicity. The aim is to improve performance and compatibility of biomedical structures. Within this context, three different systems but with similar characteristics will be investigated: (1) NSMs with bactericidal properties; (2) NSMs with virucidal properties and (3) NSMs with properties to induce the death of tumor cells in a selective manner. Characterization of nanoparticles in every step of functionalization and release tests of different drugs (active agents) will be conducted. Bioassays with susceptible and resistant bacteria, different viruses and a variety of cells will be done. This proposal is an extension and an in deep sequence of the FAPESP proposal (2011/21954-7) that ended 07/31/2014. In addition, the line of research proposed in this application will contribute to the consolidation of the research group in the areas of synthesis, functionalization, and characterization of functionalized complex systems devoted to nanomedicine applications. (AU)

Articles published in Agência FAPESP about the research grant
Nanoparticles coated with antibiotic eliminate drug-resistant bacteria 
Brazilian researchers develop nanoparticles that can inactivate HIV 

Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AFFONSO DE OLIVEIRA, JESSICA FERNANDA; SCHEFFER, FRANCINE RAMOS; LANDIS, RYAN F.; NETO, ERICO TEIXEIRA; ROTELLO, VINCENT M.; CARDOSO, MATEUS BORBA. Dual Functionalization of Nanoparticles for Generating Corona-Free and Noncytotoxic Silica Nanoparticles. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 49, p. 41917-41923, DEC 12 2018. Web of Science Citations: 0.
BOUCHMELLA, KARIM; CAMPANARO, FELIPE DAVI; MONDO, GABRIELA BORBA; SANTOS, MURILO IZIDORO; FRANCO, CAIO HADDAD; MORAES, CAROLINA BORSOI; BIOLLEY, CHRISTINE; MEHDI, AHMAD; CARDOSO, MATEUS BORBA. Tetracycline@silverions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration. Nanomedicine, v. 13, n. 14, p. 1731-1751, JUL 2018. Web of Science Citations: 1.
PICCO, AGUSTIN S.; FERREIRA, LARISSA F.; LIBERATO, MICHELLE S.; MONDO, GABRIELA B.; CARDOSO, MATEUS B. Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications. Nanomedicine, v. 13, n. 2, p. 179-190, JAN 2018. Web of Science Citations: 4.
EMER, MAIARA; CARDOSO, MATEUS BORBA. Biomolecular corona formation: nature and bactericidal impact on surface-modified silica nanoparticles. JOURNAL OF MATERIALS CHEMISTRY B, v. 5, n. 40, p. 8052-8059, OCT 28 2017. Web of Science Citations: 3.
BATISTA, CARIN C. S.; ALBUQUERQUE, LINDOMAR J. C.; RIBEIRO, CAROLINE A. S.; DE CASTRO, CARLOS E.; MIRANDA, ERICA G. A.; NANTES, ISELI L.; ALBUQUERQUE, BRUNNO L.; CARDOSO, MATEUS B.; GIACOMELLI, FERNANDO C. Nano-Sized Silver Colloids Produced and Stabilized by Amino-Functionalized Polymers: Polymer Structure-Nanoparticle Features and Polymer Structure-Growth Kinetics Relationships. Journal of the Brazilian Chemical Society, v. 28, n. 9, p. 1608-1618, SEP 2017. Web of Science Citations: 4.
DE OLIVEIRA, LUCIANE F.; BOUCHMELLA, KARIM; PICCO, AGUSTIN S.; CAPELETTI, LARISSA B.; GONCALVES, KALIANDRA A.; DOS SANTOS, JOAO HENRIQUE Z.; KOBARG, JORG; CARDOSO, MATEUS B. Tailored Silica Nanoparticles Surface to Increase Drug Load and Enhance Bactericidal Response. Journal of the Brazilian Chemical Society, v. 28, n. 9, p. 1715-1724, SEP 2017. Web of Science Citations: 6.
AFFONSO DE OLIVEIRA, JESSICA FERNANDA; SAITO, ANGELA; BIDO, ARIADNE TUCKMANTEL; KOBARG, JOERG; STASSEN, HUBERT KARL; CARDOSO, MATEUS BORBA. Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles. SCIENTIFIC REPORTS, v. 7, MAY 2 2017. Web of Science Citations: 12.
Tailored Silica Nanoparticles Surface to Increase Drug Load and Enhance Bactericidal Response. Journal of the Brazilian Chemical Society, v. 28, n. 9, p. -, Set. 2017.
CAPELETTI, LARISSA BRENTANO; CARDOSO, MATEUS BORBA; ZIMNOCH DOS SANTOS, JOAO HENRIQUE; HE, WEI. Hybrid Thin Film Organosilica Sol-Gel Coatings To Support Neuronal Growth and Limit Astrocyte Growth. ACS APPLIED MATERIALS & INTERFACES, v. 8, n. 41, p. 27553-27563, OCT 19 2016. Web of Science Citations: 4.
DE SOUZA E SILVA, JULIANA MARTINS; MELO HANCHUK, TALITA DINIZ; SANTOS, MURILO IZIDORO; KOBARG, JOERG; BAJGELMAN, MARCIO CHAIM; CARDOSO, MATEUS BORBA. Viral Inhibition Mechanism Mediated by Surface-Modified Silica Nanoparticles. ACS APPLIED MATERIALS & INTERFACES, v. 8, n. 26, p. 16564-16572, JUL 6 2016. Web of Science Citations: 13.
DE OLIVEIRA, LUCIANE FRANCA; BOUCHMELLA, KARIM; GONCALVES, KALIANDRA DE ALMEIDA; BETTINI, JEFFERSON; KOBARG, JOERG; CARDOSO, MATEUS BORBA. Functionalized Silica Nanoparticles As an Alternative Platform for Targeted Drug-Delivery of Water Insoluble Drugs. Langmuir, v. 32, n. 13, p. 3217-3225, APR 5 2016. Web of Science Citations: 34.
DE BARROS, HELOISE RIBEIRO; CARDOSO, MATEUS BORBA; DE OLIVEIRA, CAROLINA CAMARGO; CAVICHIOLO FRANCO, CELIA REGINA; BELAN, DANIEL DE LIMA; VIDOTTI, MARCIO; RIEGEL-VIDOTTI, IZABEL C. Stability of gum arabic-gold nanoparticles in physiological simulated pHs and their selective effect on cell lines. RSC ADVANCES, v. 6, n. 12, p. 9411-9420, 2016. Web of Science Citations: 10.
SILVA, HELOIZA F. O.; LIMA, KASSIO M. G.; CARDOSO, MATEUS B.; OLIVEIRA, JESSICA F. A.; MELO, MARIA C. N.; SANT'ANNA, CELSO; EUGENIO, MATEUS; GASPAROTTO, LUIZ H. S. Doxycycline conjugated with polyvinylpyrrolidone-encapsulated silver nanoparticles: a polymer's malevolent touch against Escherichia coli. RSC ADVANCES, v. 5, n. 82, p. 66886-66893, 2015. Web of Science Citations: 11.

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