Functionalization of silica nanoparticles: increasing biological interaction

• Grant number: 14/22322-2
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2015
• End date: May 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Mateus Borba Cardoso
• Grantee: Mateus Borba Cardoso
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Associated researchers: Bouchmella Karim ; Carlos Sato Baraldi Dias ; Jörg Kobarg ; Juliana Martins de Souza e Silva ; Marcio Chaim Bajgelman

Abstract

The proposal described here aims to surface functionalization of mesoporous silica nanoparticles (NSMs) in order to increase the biological effectiveness and reduce the cytotoxicity. The aim is to improve performance and compatibility of biomedical structures. Within this context, three different systems but with similar characteristics will be investigated: (1) NSMs with bactericidal properties; (2) NSMs with virucidal properties and (3) NSMs with properties to induce the death of tumor cells in a selective manner. Characterization of nanoparticles in every step of functionalization and release tests of different drugs (active agents) will be conducted. Bioassays with susceptible and resistant bacteria, different viruses and a variety of cells will be done. This proposal is an extension and an in deep sequence of the FAPESP proposal (2011/21954-7) that ended 07/31/2014. In addition, the line of research proposed in this application will contribute to the consolidation of the research group in the areas of synthesis, functionalization, and characterization of functionalized complex systems devoted to nanomedicine applications. (AU)

Scientific publications

(18)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BATISTA, CARIN C. S.; ALBUQUERQUE, LINDOMAR J. C.; RIBEIRO, CAROLINE A. S.; DE CASTRO, CARLOS E.; MIRANDA, ERICA G. A.; NANTES, ISELI L.; ALBUQUERQUE, BRUNNO L.; CARDOSO, MATEUS B.; GIACOMELLI, FERNANDO C.. Nano-Sized Silver Colloids Produced and Stabilized by Amino-Functionalized Polymers: Polymer Structure-Nanoparticle Features and Polymer Structure-Growth Kinetics Relationships. Journal of the Brazilian Chemical Society, v. 28, n. 9, p. 1608-1618, SEP 2017. (14/22983-9, 14/22322-2, 15/24686-4)

AFFONSO DE OLIVEIRA, JESSICA FERNANDA; DA SILVA, RAQUEL FRENEDOSO; SOUSA RIBEIRO, IRIS RENATA; SAITO, ANGELA; MELO-HANCHUK, TALITA DINIZ; DIAS, MARILIA MEIRA; KOBARG, JORG; CARDOSO, MATEUS BORBA. Selective Targeting of Lymphoma Cells by Monoclonal Antibody Grafted onto Zwitterionic-Functionalized Nanoparticles. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, v. 37, n. 3, FEB 2020. (14/22322-2, 15/25406-5, 13/22429-9, 17/21318-0)

EMER, MAIARA; CARDOSO, MATEUS BORBA. Biomolecular corona formation: nature and bactericidal impact on surface-modified silica nanoparticles. JOURNAL OF MATERIALS CHEMISTRY B, v. 5, n. 40, p. 8052-8059, OCT 28 2017. (14/01241-4, 14/22322-2, 15/25406-5)

DE BARROS, HELOISE RIBEIRO; CARDOSO, MATEUS BORBA; DE OLIVEIRA, CAROLINA CAMARGO; CAVICHIOLO FRANCO, CELIA REGINA; BELAN, DANIEL DE LIMA; VIDOTTI, MARCIO; RIEGEL-VIDOTTI, IZABEL C.. Stability of gum arabic-gold nanoparticles in physiological simulated pHs and their selective effect on cell lines. RSC ADVANCES, v. 6, n. 12, p. 9411-9420, 2016. (11/21954-7, 14/22322-2)

DE OLIVEIRA, LUCIANE FRANCA; BOUCHMELLA, KARIM; GONCALVES, KALIANDRA DE ALMEIDA; BETTINI, JEFFERSON; KOBARG, JOERG; CARDOSO, MATEUS BORBA. Functionalized Silica Nanoparticles As an Alternative Platform for Targeted Drug-Delivery of Water Insoluble Drugs. Langmuir, v. 32, n. 13, p. 3217-3225, APR 5 2016. (14/22322-2)

AFFONSO DE OLIVEIRA, JESSICA FERNANDA; SAITO, ANGELA; BIDO, ARIADNE TUCKMANTEL; KOBARG, JOERG; STASSEN, HUBERT KARL; CARDOSO, MATEUS BORBA. Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles. SCIENTIFIC REPORTS, v. 7, MAY 2 2017. (14/22322-2, 11/15937-2, 15/25406-5)

CAPELETTI, LARISSA BRENTANO; CARDOSO, MATEUS BORBA; ZIMNOCH DOS SANTOS, JOAO HENRIQUE; HE, WEI. Hybrid Thin Film Organosilica Sol-Gel Coatings To Support Neuronal Growth and Limit Astrocyte Growth. ACS APPLIED MATERIALS & INTERFACES, v. 8, n. 41, p. 27553-27563, OCT 19 2016. (14/22322-2)

SILVA, HELOIZA F. O.; LIMA, KASSIO M. G.; CARDOSO, MATEUS B.; OLIVEIRA, JESSICA F. A.; MELO, MARIA C. N.; SANT'ANNA, CELSO; EUGENIO, MATEUS; GASPAROTTO, LUIZ H. S.. Doxycycline conjugated with polyvinylpyrrolidone-encapsulated silver nanoparticles: a polymer's malevolent touch against Escherichia coli. RSC ADVANCES, v. 5, n. 82, p. 66886-66893, 2015. (14/22322-2)

AFFONSO DE OLIVEIRA, JESSICA FERNANDA; CAPELETTI, LARISSA BRENTANO; CARDOSO, MATEUS BORBA. Are antibiotic-functionalized nanoparticles a promising tool in antimicrobial therapies?. Nanomedicine, v. 12, n. 23, p. 4-pg., 2017-12-01. (17/01167-7, 15/25406-5, 14/22322-2, 13/22429-9)

BATISTA, CARIN C. S.; ALBUQUERQUE, LINDOMAR J. C.; RIBEIRO, CAROLINE A. S.; DE CASTRO, CARLOS E.; MIRANDA, ERICA G. A.; NANTES, ISELI L.; ALBUQUERQUE, BRUNNO L.; CARDOSO, MATEUS B.; GIACOMELLI, FERNANDO C.. Nano-Sized Silver Colloids Produced and Stabilized by Amino-Functionalized Polymers: Polymer Structure-Nanoparticle Features and Polymer Structure-Growth Kinetics Relationships. Journal of the Brazilian Chemical Society, v. 28, n. 9, p. 11-pg., 2017-09-01. (15/24686-4, 14/22983-9, 14/22322-2)

DE OLIVEIRA, LUCIANE F.; BOUCHMELLA, KARIM; PICCO, AGUSTIN S.; CAPELETTI, LARISSA B.; GONCALVES, KALIANDRA A.; DOS SANTOS, JOAO HENRIQUE Z.; KOBARG, JORG; CARDOSO, MATEUS B.. Tailored Silica Nanoparticles Surface to Increase Drug Load and Enhance Bactericidal Response. Journal of the Brazilian Chemical Society, v. 28, n. 9, p. 1715-1724, SEP 2017. (14/22322-2, 15/25406-5)

PICCO, AGUSTIN S.; FERREIRA, LARISSA F.; LIBERATO, MICHELLE S.; MONDO, GABRIELA B.; CARDOSO, MATEUS B.. Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications. Nanomedicine, v. 13, n. 2, p. 179-190, JAN 2018. (16/16905-0, 15/25406-5, 14/22322-2, 14/21910-8, 17/02145-7)

BOUCHMELLA, KARIM; CAMPANARO, FELIPE DAVI; MONDO, GABRIELA BORBA; SANTOS, MURILO IZIDORO; FRANCO, CAIO HADDAD; MORAES, CAROLINA BORSOI; BIOLLEY, CHRISTINE; MEHDI, AHMAD; CARDOSO, MATEUS BORBA. Tetracycline@silverions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration. Nanomedicine, v. 13, n. 14, p. 1731-1751, JUL 2018. (14/22322-2, 15/25406-5, 16/16905-0)

PICCO, AGUSTIN S.; MONDO, GABRIELA BORBA; FERREIRA, LARISSA FERNANDA; DE SOUZA, EDMARCIA ELISA; PERONI, LUIS ANTONIO; CARDOSO, MATEUS BORBA. Protein corona meets freeze-drying: overcoming the challenges of colloidal stability, toxicity, and opsonin adsorption. NANOSCALE, v. 13, n. 2, p. 753-762, JAN 14 2021. (17/02145-7, 14/22322-2, 15/25406-5)

AFFONSO DE OLIVEIRA, JESSICA FERNANDA; SCHEFFER, FRANCINE RAMOS; LANDIS, RYAN F.; NETO, ERICO TEIXEIRA; ROTELLO, VINCENT M.; CARDOSO, MATEUS BORBA. Dual Functionalization of Nanoparticles for Generating Corona-Free and Noncytotoxic Silica Nanoparticles. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 49, p. 41917-41923, DEC 12 2018. (15/25406-5, 14/22322-2, 13/22429-9, 15/21918-1)

DE SOUZA E SILVA, JULIANA MARTINS; MELO HANCHUK, TALITA DINIZ; SANTOS, MURILO IZIDORO; KOBARG, JOERG; BAJGELMAN, MARCIO CHAIM; CARDOSO, MATEUS BORBA. Viral Inhibition Mechanism Mediated by Surface-Modified Silica Nanoparticles. ACS APPLIED MATERIALS & INTERFACES, v. 8, n. 26, p. 16564-16572, JUL 6 2016. (13/12190-9, 14/22322-2, 12/05481-4)

BOUCHMELLA, KARIM; LION, QUENTIN; GERVAIS, CHRISTEL; CARDOSO, MATEUS BORBA. Impact of Mesoporous Silica Functionalization Fine-Tuning on Antibiotic Uptake/Delivery and Bactericidal Activity. ACS OMEGA, v. 8, n. 13, p. 11-pg., 2023-03-22. (21/12071-6, 15/25406-5, 14/22322-2)

DE OLIVEIRA, LUCIANE F.; BOUCHMELLA, KARIM; PICCO, AGUSTIN S.; CAPELETTI, LARISSA B.; GONCALVES, KALIANDRA A.; DOS SANTOS, JOAO HENRIQUE Z.; KOBARG, JORG; CARDOSO, MATEUS B.. Tailored Silica Nanoparticles Surface to Increase Drug Load and Enhance Bactericidal Response. Journal of the Brazilian Chemical Society, v. 28, n. 9, p. 10-pg., 2017-09-01. (15/25406-5, 14/22322-2)