Colloidal stability and protein corona: fundamental aspects for maintaining silica nanoparticle properties in biologial media

• Grant number: 16/16905-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: September 01, 2016
• End date: January 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Mateus Borba Cardoso
• Grantee: Gabriela Borba Mondo
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Associated research grant: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM
• Associated scholarship(s): 19/26789-6 - Zwitterionic peptide-conjugated silica nanoparticles for improved proprieties towards nanomedical applications, BE.EP.DD

Abstract

Nanoparticles are promising plataforms for applications in biological systems due to their size and functionalization possibilities. However, loss of colloidal stability and formation of protein corona has hindered clinical translation of nanoparticles. This change in colloidal stability and the formation of protein corona influence the final characteristics of the nanoparticles and their physical-chemical properties. creating a new biological identity for the nanomaterial. The goal here is to study the colloidal stability and the protein corona formation over silica nanoparticles of approximately 100 nm with different surface modifications. Particularly, evaluation of silica nanoparticles with a zwitterionic silane will be studied, to elucidate aspects that grant colloidal stability to these nanoparticles when in biological fluids. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOIOLA, LIVIA M. D.; BATISTA, MARINA; CAPELETTI, LARISSA B.; MONDO, GABRIELA B.; ROSA, RHUBIA S. M.; MARQUES, RAFAEL E.; BAJGELMAN, MARCIO C.; CARDOSO, MATEUS B.. Shielding and stealth effects of zwitterion moieties in double-functionalized silica nanoparticles. Journal of Colloid and Interface Science, v. 553, p. 540-548, OCT 1 2019. (17/09203-2, 15/25406-5, 16/21598-0, 17/01167-7, 17/06692-2, 16/16905-0)

PICCO, AGUSTIN S.; FERREIRA, LARISSA F.; LIBERATO, MICHELLE S.; MONDO, GABRIELA B.; CARDOSO, MATEUS B.. Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications. Nanomedicine, v. 13, n. 2, p. 179-190, JAN 2018. (16/16905-0, 15/25406-5, 14/22322-2, 14/21910-8, 17/02145-7)

DA CRUZ SCHNEID, ANDRESSA; ALBUQUERQUE, LINDOMAR JOSE CALUMBY; MONDO, GABRIELA BORBA; CEOLIN, MARCELO; PICCO, AGUSTIN SILVIO; CARDOSO, MATEUS BORBA. Colloidal stability and degradability of silica nanoparticles in biological fluids: a review. Journal of Sol-Gel Science and Technology, JAN 2022. (16/16905-0, 20/00767-3, 15/25406-5, 18/00763-8, 19/24894-7)

BOUCHMELLA, KARIM; CAMPANARO, FELIPE DAVI; MONDO, GABRIELA BORBA; SANTOS, MURILO IZIDORO; FRANCO, CAIO HADDAD; MORAES, CAROLINA BORSOI; BIOLLEY, CHRISTINE; MEHDI, AHMAD; CARDOSO, MATEUS BORBA. Tetracycline@silverions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration. Nanomedicine, v. 13, n. 14, p. 1731-1751, JUL 2018. (14/22322-2, 15/25406-5, 16/16905-0)

CATHCARTH, MARILINA; PICCO, AGUSTIN S.; MONDO, GABRIELA B.; CARDOSO, MATEUS B.; LONGO, GABRIEL S.. Competitive protein adsorption on charge regulating silica-like surfaces: the role of protonation equilibrium. JOURNAL OF PHYSICS-CONDENSED MATTER, v. 34, n. 36, p. 13-pg., 2022-09-07. (16/16905-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MONDO, Gabriela Borba. Colloidal stability and protein corona: fundamental aspects for maintaining silica nanoparticle properties in biological media. 2022. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.