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Correlation between the protein corona and biological activity of silica nanoparticles

Grant number: 16/16905-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): September 01, 2016
Effective date (End): August 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Mateus Borba Cardoso
Grantee:Gabriela Borba Mondo
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Campinas , SP, Brazil
Associated research grant:15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM
Associated scholarship(s):19/26789-6 - Zwitterionic peptide-conjugated silica nanoparticles for improved proprieties towards nanomedical applications, BE.EP.DD


Nanoparticles are promising systems for using in biological media due to their size and functionalization possibilities. However, these nanoparticles when in contact with biological fluids which are rich in proteins and other biomolecules form a protein layer called protein corona. It influences the final characteristics of the nanoparticles and their physical-chemical properties. Each nanomaterial has a distinct protein corona and this corona changes the size and the interface composition of the nanomaterial, thus creating a new identity for the biological material. The purpose here is to study the process of protein corona formation over silica nanoparticles of approximately 100 nm. Nanoparticles with different surfaces will be incubated with model proteins (human serum albumin, fibrinogen and human ³-globulin), and for those more promising systems the proteins will be chemically bound to the surface of the nanoparticles inducing the hard corona formation. Biological properties of these different synthesized systems will be studied and apoptotic induction profile will be investigated for both systems (either with adsorbed proteins or with chemically bound). (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOIOLA, LIVIA M. D.; BATISTA, MARINA; CAPELETTI, LARISSA B.; MONDO, GABRIELA B.; ROSA, RHUBIA S. M.; MARQUES, RAFAEL E.; BAJGELMAN, MARCIO C.; CARDOSO, MATEUS B. Shielding and stealth effects of zwitterion moieties in double-functionalized silica nanoparticles. Journal of Colloid and Interface Science, v. 553, p. 540-548, OCT 1 2019. Web of Science Citations: 3.
BOUCHMELLA, KARIM; CAMPANARO, FELIPE DAVI; MONDO, GABRIELA BORBA; SANTOS, MURILO IZIDORO; FRANCO, CAIO HADDAD; MORAES, CAROLINA BORSOI; BIOLLEY, CHRISTINE; MEHDI, AHMAD; CARDOSO, MATEUS BORBA. Tetracycline@silverions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration. Nanomedicine, v. 13, n. 14, p. 1731-1751, JUL 2018. Web of Science Citations: 2.
PICCO, AGUSTIN S.; FERREIRA, LARISSA F.; LIBERATO, MICHELLE S.; MONDO, GABRIELA B.; CARDOSO, MATEUS B. Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications. Nanomedicine, v. 13, n. 2, p. 179-190, JAN 2018. Web of Science Citations: 6.

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