The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose

Autor(es)

Elias, Luciana M. ^[1] ; Fortlzamp, Diana ^[1] ; Sartori, Sergio B. ^[1] ; Ferreira, Marilia C. ^[1] ; Gomes, Luiz H. ^[1] ; Azevedo, Joao L. ^[2] ; Montoya, V, Quimi ; Rodrigues, Andre ^[3] ; Ferreira, Antonio G. ^[4] ; Lira, Simone P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Ciencias Exatas, Escola Super Agr Luiz de Queiroz, Piracicaba, SP - Brazil

^[2] Univ Sao Paulo, Dept Genet, Escola Super Agr Luiz de Queiroz, Piracicaba, SP - Brazil

^[3] Montoya, Quimi, V, Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Rio Claro, SP - Brazil

^[4] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Microbiology; v. 49, n. 4, p. 840-847, OCT-DEC 2018.
• Citações Web of Science: 2

Resumo

Anthracnose is a crop disease usually caused by fungi in the genus Colletotrichum or Gloeosporium. These are considered one of the main pathogens, causing significant economic losses, such as in peppers and guarana. The current forms of control include the use of resistant cultivars, sanitary pruning and fungicides. However, even with the use of some methods of controlling these cultures, the crops are not free of anthracnose. Additionally, excessive application of fungicides increases the resistance of pathogens to agrochemicals and cause harm to human health and the environment. In order to find natural antifungal agents against guarana anthracnose, endophytic fungi were isolated from Amazon guarana. The compounds piliformic acid and cytochalasin D were isolated by chromatographic techniques from two Xylaria spp., guided by assays with Colletotrichum gloeosporioides. The isolated compounds were identified by spectrometric techniques, as NMR and mass spectrometry. This is the first report that piliformic acid and cytochalasin D have antifungal activity against C. gloeosporioides with MIC 2.92 and 2.46 mu mol mL(-1) respectively. Captan and difenocona-zole were included as positive controls (MIC 16.63 and 0.02 mu mol mL(-1), respectively). Thus, Xylaria species presented a biotechnological potential and production of different active compounds which might be promising against anthracnose disease. (C) 2018 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. (AU)

• Processo FAPESP: 13/50228-8 - Componentes da biodiversidade, e seus caracteres metabólicos, de ilhas do Brasil - uma abordagem integrada
• Beneficiário: Roberto Gomes de Souza Berlinck
• Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 14/15760-3 - Potencial biotecnológico de metabólitos secundários de plantas e fungos endofíticos
• Beneficiário: Simone Possedente de Lira
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/02000-5 - Bioprospecção de fungos endofíticos isolados de guaranazeiros da Amazônia
• Beneficiário: Luciana Mecatti Elias
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/05940-4 - Estudo químico e biológico de 2 linhagens de fungos endofíticos isolados de folhas de guaranazeiros do Amazonas
• Beneficiário: Marília Capellaro Ferreira
• Linha de fomento: Bolsas no Brasil - Iniciação Científica