Multidrug-resistant CDX-M-15-producing Klebsiella pneumoniae ST231 associated with infection and persistent colonization of dog

Autor(es)

Silva, Meire M. ^[1] ; Fernandes, Miriam R. ^[2] ; Sellera, Fabio P. ^[3] ; Cerdeira, Louise ^[2] ; Medeiros, Lylian K. G. ^[1] ; Garino, Felicio ^[1] ; Azevedo, Sergio S. ^[1] ; Lincopan, Nilton ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed Campina Grande, Acad Vet Med Unit, Patos de Minas, Paraiba - Brazil

^[2] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Internal Med, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 92, n. 3, p. 259-261, NOV 2018.
• Citações Web of Science: 2

Resumo

Extended spectrum beta-lactamase (ESBL)-producing bacterial infections in veterinary medicine are a clinical and epidemiological challenge. We report a case of CTX-M-15-producing Klebsiella pneumoniae infection followed by persistent colonization, in a dog presenting with bilateral purulent nasal discharge and dyspnea. In this regard, 5 broad-spectrum cephalosporin-resistant K. pneumoniae isolates were recovered from infection and surveillance cultures, collected during 1 year and eight months study. Genomic analysis of a representative clone of K. pneumoniae (KpPB76) revealed the presence of the human-associated lineage ST231, whereas resistome data confirmed the presence of genes conferring resistance to aminoglycosides, beta-lactams, fluoroquinolones, fosfomycin, phenicols, sulfonamides, tetracyclines and trimethoprim. In the absence of therapeutic options, meropenem therapy was used, contributing to the control of infection during persistent carriage of K. pneumoniae CTX-M-15/ST231. Persistent colonization of companion animals with ESBL-producing bacteria could be result from a variety of situations, including multi introduction from the owner or household family members to pets, or from environmental exposure; whereas colonized animals may serve as an important source for the spread of ESBL-producing strains in the human-animal interface. (C) 2018 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 16/08593-9 - Pan-resistoma de Klebsiella pneumoniae e Escherichia coli produtoras de beta-lactamases (KPC-2, CTX-M-8, CTX-M-15) endêmicas no Brasil
• Beneficiário: Nilton Erbet Lincopan Huenuman
• Modalidade de apoio: Auxílio à Pesquisa - Regular