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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multidrug-resistant CDX-M-15-producing Klebsiella pneumoniae ST231 associated with infection and persistent colonization of dog

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Author(s):
Silva, Meire M. [1] ; Fernandes, Miriam R. [2] ; Sellera, Fabio P. [3] ; Cerdeira, Louise [2] ; Medeiros, Lylian K. G. [1] ; Garino, Felicio [1] ; Azevedo, Sergio S. [1] ; Lincopan, Nilton [4]
Total Authors: 8
Affiliation:
[1] Univ Fed Campina Grande, Acad Vet Med Unit, Patos de Minas, Paraiba - Brazil
[2] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Internal Med, Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 92, n. 3, p. 259-261, NOV 2018.
Web of Science Citations: 2
Abstract

Extended spectrum beta-lactamase (ESBL)-producing bacterial infections in veterinary medicine are a clinical and epidemiological challenge. We report a case of CTX-M-15-producing Klebsiella pneumoniae infection followed by persistent colonization, in a dog presenting with bilateral purulent nasal discharge and dyspnea. In this regard, 5 broad-spectrum cephalosporin-resistant K. pneumoniae isolates were recovered from infection and surveillance cultures, collected during 1 year and eight months study. Genomic analysis of a representative clone of K. pneumoniae (KpPB76) revealed the presence of the human-associated lineage ST231, whereas resistome data confirmed the presence of genes conferring resistance to aminoglycosides, beta-lactams, fluoroquinolones, fosfomycin, phenicols, sulfonamides, tetracyclines and trimethoprim. In the absence of therapeutic options, meropenem therapy was used, contributing to the control of infection during persistent carriage of K. pneumoniae CTX-M-15/ST231. Persistent colonization of companion animals with ESBL-producing bacteria could be result from a variety of situations, including multi introduction from the owner or household family members to pets, or from environmental exposure; whereas colonized animals may serve as an important source for the spread of ESBL-producing strains in the human-animal interface. (C) 2018 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 16/08593-9 - Pan-Resistome of beta-lactamase (KPC-2, CTX-M-8, CTX-M-15)-producing Klebsiella pneumoniae and Escherichia coli isolates endemic in Brazil
Grantee:Nilton Erbet Lincopan Huenuman
Support Opportunities: Regular Research Grants