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Pan-Resistome of beta-lactamase (KPC-2, CTX-M-8, CTX-M-15)-producing Klebsiella pneumoniae and Escherichia coli isolates endemic in Brazil

Abstract

The antimicrobial resistance among clinically important pathogens is a public health challenge worldwide, which exhibits a dynamic trajectory from the environment to hospital settings and vice versa. In this regard, resistance is not static, as pathogenic multidrug-resistant (MDR) bacteria strains can move among human and animals populations, as well as among diferent ecossystems. On the other hand, mobile genetic elements carrying resistance genes can move among pathogens and commensal microbiota, favouring the establishment and endemicity of high-risk MDR clones (clonal complexes). The effective management and treatment of infections caused by MDR bacteria, the epidemiology and control of related infections and the discovery and development of new antimicrobial agents increasingly rely upon genotype information "the resistome", supported by next-generation DNA sequencing methods (NGS). This research project aims to obtain a sequence database that allows bioinformatic analysis of pan-resistoma strains of Klebsiella pneumoniae and Escherichia coli producing beta-lactamases (KPC-2, CTX-M-8, CTX- M-15) endemics in Brazil, isolated from human, veterinary and environment samples. The results will contribute to the creation of a reference sequence platform that may be used in diagnostic, therapeutic and/or epidemiological control, among others; elucidating "a priori" genetic aspects of adaptation, resistance and virulence of endemic clones. (AU)

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Scientific publications (38)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SELLERA, FABIO P.; FUGA, BRUNA; FONTANA, HERRISON; ESPOSITO, FERNANDA; CARDOSO, BRENDA; KONNO, SIBELE; BERL, CARLA; CAPPELLANES, MARIANA H.; CORTEZ, MARCIA; IKEDA, MARCELO; DE SOUZA, CESAR M.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Detection of IncN-pST15 one-health plasmid harbouring bla(KPC-2) in a hypermucoviscous Klebsiella pneumoniae CG258 isolated from an infected dog, Brazil. TRANSBOUNDARY AND EMERGING DISEASES, FEB 2021. Web of Science Citations: 0.
LOPES, RALF; FUENTES-CASTILLO, DANNY; FONTANA, HERRISON; RODRIGUES, LARISSA; DANTAS, KARINE; CERDEIRA, LOUISE; HENRIQUES, ISABEL; LINCOPAN, NILTON. Endophytic Lifestyle of Global Clones of Extended-Spectrum beta-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?. MSYSTEMS, v. 6, n. 1 JAN-FEB 2021. Web of Science Citations: 1.
FERREIRA, THALITA C. S.; SAUTER, ISMAEL P.; BORDA-SAMPER, LINA; BENTIVOGLIO, ENYD; DAMATA, JARINA P.; TANIWAKI, NOEMI N.; ORREGO, PATRICIO R.; ARAYA, JORGE E.; LINCOPAN, NILTON; CORTEZ, MAURO. Effect of DODAB Nano-Sized Cationic Bilayer Fragments against Leishmania amazonensis. Molecules, v. 25, n. 23 DEC 2020. Web of Science Citations: 1.
CERDEIRA, LOUISE; MONTE, DANIEL F. M.; FUGA, BRUNA; SELLERA, FABIO P.; NEVES, INGRITH; RODRIGUES, LARISSA; LANDGRAF, MARIZA; LINCOPAN, NILTON. Genomic insights of Klebsiella pneumoniae isolated from a native Amazonian fish reveal wide resistome against heavy metals, disinfectants, and clinically relevant antibiotics. Genomics, v. 112, n. 6, p. 5143-5146, NOV 2020. Web of Science Citations: 0.
DE CARVALHO, MARCELO P. N.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; LOPES, RALF; MONTE, DANIEL F.; HIPPOLITO, ALICIA G.; MILANELO, LILIANE; RASO, TANIA F.; LINCOPAN, NILTON. International clones of extended-spectrum beta-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil. TRANSBOUNDARY AND EMERGING DISEASES, v. 67, n. 5, p. 1804-1815, SEP 2020. Web of Science Citations: 4.
SABINO, CAETANO PADIAL; WAINWRIGHT, MARK; RIBEIRO, MARTHA SIMOES; SELLERA, FABIO PARRA; DOS ANJOS, CAROLINA; BAPTISTA, MAURICIO DA SILVA; LINCOPAN, NILTON. Global priority multidrug-resistant pathogens do not resist photodynamic therapy. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 208, JUL 2020. Web of Science Citations: 13.
SARTORI, LUCIANA; SELLERA, FABIO P.; MOURA, QUEZIA; CARDOSO, BRENDA; FONTANA, HERRISON; CORTES, LUCAS A.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Genomic features of a polymyxin-resistant Klebsiella pneumoniae ST491 isolate co-harbouring bla(CTX-M-8) and qnrE1 genes from a hospitalised cat in Sao Paulo, Brazil. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 21, p. 186-187, JUN 2020. Web of Science Citations: 0.
DE CARVALHO, MARCELO P. N.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; LOPES, RALF; MONTE, DANIEL F.; HIPPOLITO, ALICIA G.; MILANELO, LILIANE; RASO, TANIA F.; LINCOPAN, NILTON. International clones of extended-spectrum beta-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil. TRANSBOUNDARY AND EMERGING DISEASES, v. 67, n. 5 APR 2020. Web of Science Citations: 3.
DOS ANJOS, C.; SELLERA, F. P.; DE FREITAS, L. M.; GARGANO, R. G.; TELLES, E. O.; FREITAS, R. O.; BAPTISTA, M. S.; RIBEIRO, M. S.; LINCOPAN, N.; POGLIANI, F. C.; SABINO, C. P. Inactivation of milk-borne pathogens by blue light exposure. JOURNAL OF DAIRY SCIENCE, v. 103, n. 2, p. 1261-1268, FEB 2020. Web of Science Citations: 0.
FERNANDES, MIRIAM R.; SELLERA, FABIO P.; MOURA, QUEZIA; ESPOSITO, FERNANDA; SABINO, CAETANO P.; LINCOPAN, NILTON. Identification and genomic features of halotolerant extended-spectrum-beta-lactamase (CTX-M)-producing Escherichia coli in urban-impacted coastal waters, Southeast Brazil. Marine Pollution Bulletin, v. 150, JAN 2020. Web of Science Citations: 0.
ZAMPARETTE, CAETANA P.; SCHORNER, MARCOS; CAMPOS, ELIZANDRA; MOURA, QUEZIA; CERDEIRA, LOUISE; TARTARI, DANIELA C.; SEREIA, ALINE F. R.; CUNHA, PATRICIA; FONTANA, HERRISON; DE OLIVEIRA, LUIZ FELIPE V.; GRISARD, EDMUNDO C.; LINCOPAN, NILTON; BAZZO, MARIA LUIZA; SINCERO, THAIS C. M. IncX4 Plasmid-Mediated mcr-1.1 in Polymyxin-Resistant Escherichia coli from Outpatients in Santa Catarina, Southern Brazil. MICROBIAL DRUG RESISTANCE, v. 26, n. 11 JAN 2020. Web of Science Citations: 1.
SABINO, CAETANO P.; WAINWRIGHT, MARK; DOS ANJOS, CAROLINA; SELLERA, FABIO P.; BAPTISTA, MAURICIO S.; LINCOPAN, NILTON; RIBEIRO, MARTHA S. Inactivation kinetics and lethal dose analysis of antimicrobial blue light and photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 28, p. 186-191, DEC 2019. Web of Science Citations: 1.
VALENCIA-BACCA, JUAN; SILVA, MEIRE M.; CERDEIRA, LOUISE; ESPOSITO, FERNANDA; CARDOSO, BRENDA; MUNOZ, MARIA E.; JIMENEZ-VILLEGAS, TATIANA; CARDENAS-ARIAS, ADRIANA; PESSOA, DANIELLE A. N.; LINCOPAN, NILTON. Detection and Whole-Genome Analysis of a High-Risk Clone of Klebsiella pneumoniae ST340/CG258 Producing CTX-M-15 in a Companion Animal. MICROBIAL DRUG RESISTANCE, v. 26, n. 6 DEC 2019. Web of Science Citations: 0.
MOHSIN, MASHKOOR; AZAM, MARIYA; RAHMAN, SAJJAD UR; ESPOSITO, FERNANDA; SELLERA, FABIO P.; MONTE, DANIEL F.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Genomic background of a colistin-resistant and highly virulent MCR-1-positive Escherichia coli ST6395 from a broiler chicken in Pakistan. PATHOGENS AND DISEASE, v. 77, n. 7 OCT 2019. Web of Science Citations: 0.
DOS ANJOS, CAROLINA; SABINO, CAETANO P.; BUERIS, VANESSA; FERNANDES, MIRIAM R.; POGLIANI, FABIO C.; LINCOPAN, NILTON; SELLERA, FABIO P. Antimicrobial blue light inactivation of international clones of multidrug-resistant Escherichia coli ST10, ST131 and ST648. Photodiagnosis and Photodynamic Therapy, v. 27, p. 51-53, SEP 2019. Web of Science Citations: 0.
OPAZO-CAPURRO, ANDRES; SAN MARTIN, IVAN; QUEZADA-AGUILUZ, MARIO; MORALES-LEON, FELIPE; DOMINGUEZ-YEVENES, MARIANA; LIMA, CELIA A.; ESPOSITO, FERNANDA; CERDEIRA, LOUISE; BELLO-TOLEDO, HELIA; LINCOPAN, NILTON; GONZALEZ-ROCHA, GERARDO. Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals. INFECTION GENETICS AND EVOLUTION, v. 73, p. 93-97, SEP 2019. Web of Science Citations: 4.
GOLDBERG, DAPHNE W.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; COSTA, DANIELA G. C.; LOUREIRO BRACARENSE, ANA PAULA; LINCOPAN, NILTON. Genetic background of CTX-M-15-producing Enterobacter hormaechei ST114 and Citrobacter freundii ST265 co-infecting a free-living green turtle (Chelonia mydas). ZOONOSES AND PUBLIC HEALTH, v. 66, n. 5, p. 540-545, AUG 2019. Web of Science Citations: 0.
FUENTES-CASTILLO, DANNY; FARFAN-LOPEZ, MARIELLA; ESPOSITO, FERNANDA; MOURA, QUEZIA; FERNANDES, MIRIAM R.; LOPES, RALF; CARDOSO, BRENDA; MUNOZ, MARIA E.; CERDEIRA, LOUISE; NAJLE, IGNACIA; MUNOZ, PATRICIOM.; CATAO-DIAS, JOSE L.; GONZALEZ-ACUNA, DANIEL; LINCOPAN, NILTON. Wild owls colonized by international clones of extended-spectrum beta-lactamase (CTX-M)-producing Escherichia coli and Salmonella Infantis in the Southern Cone of America. Science of The Total Environment, v. 674, p. 554-562, JUL 15 2019. Web of Science Citations: 1.
SACRAMENTO, ANDREY G.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; DOLABELLA, SILVIO S.; ZANELLA, ROSEMEIRE C.; CERDEIRA, LOUISE; LINCOPAN, NILTON. VanA-type vancomycin-resistant Enterococcus faecium ST1336 isolated from mussels in an anthropogenically impacted ecosystem. Marine Pollution Bulletin, v. 142, p. 533-536, MAY 2019. Web of Science Citations: 0.
SELLERA, FABIO P.; FERNANDES, MIRIAM R.; SABINO, CAETANO P.; DE FREITAS, LAURA M.; DA SILVA, LUCIANO C. B. A.; POGLIANI, FABIO C.; RIBEIRO, MARTHA S.; HAMBLIN, MICHAEL R.; LINCOPAN, NILTON. Effective treatment and decolonization of a dog infected with carbapenemase (VIM-2)-producing Pseudomonas aeruginosa using probiotic and photodynamic therapies. VETERINARY DERMATOLOGY, v. 30, n. 2, p. 170+, APR 2019. Web of Science Citations: 1.
CASTELANI, L.; ARCARO, J. R. P.; BRAGA, J. E. P.; ROSSO, A. S.; MOURA, Q.; ESPOSITO, F.; SAUTER, I. P.; CORTEZ, M.; LINCOPAN, N. Short communication: Activity of nisin, lipid bilayer fragments and cationic nisin-lipid nanoparticles against multidrug-resistant Staphylococcus spp. isolated from bovine mastitis. JOURNAL OF DAIRY SCIENCE, v. 102, n. 1, p. 678-683, JAN 2019. Web of Science Citations: 0.
SILVA, MEIRE M.; FERNANDES, MIRIAM R.; SELLERA, FABIO P.; CERDEIRA, LOUISE; MEDEIROS, LYLIAN K. G.; GARINO, FELICIO; AZEVEDO, SERGIO S.; LINCOPAN, NILTON. Multidrug-resistant CDX-M-15-producing Klebsiella pneumoniae ST231 associated with infection and persistent colonization of dog. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 92, n. 3, p. 259-261, NOV 2018. Web of Science Citations: 2.
SELLERA, FABIO P.; FERNANDES, MIRIAM R.; MOURA, QUEZIA; CARVALHO, MARCELO P. N.; LINCOPAN, NILTON. Extended-spectrum-beta-lactamase (CTX-M)-producing Escherichia coli in wild fishes from a polluted area in the Atlantic Coast of South America. Marine Pollution Bulletin, v. 135, p. 183-186, OCT 2018. Web of Science Citations: 5.
MOURA, QUEZIA; CERDEIRA, LOUISE; FERNANDES, MIRIAM R.; VIANELLO, MARCO A.; LINCOPAN, NILTON. Novel class 1 integron (In1390) harboring bla(GES)(-5) in a Morganella morganii strain recovered from a remote community. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 91, n. 4, p. 345-347, AUG 2018. Web of Science Citations: 0.
MELO, LUANA C.; ORESCO, CINTIA; LEIGUE, LUCIANNE; NETTO, HILDEBRANDO M.; MELVILLE, PRISCILLA A.; BENITES, NILSON R.; SARAS, ESTELLE; HAENNI, MARISA; LINCOPAN, NILTON; MADEC, JEAN-YVES. Prevalence and molecular features of ESBL/pAmpC-producing Enterobacteriaceae in healthy and diseased companion animals in Brazil. Veterinary Microbiology, v. 221, p. 59-66, JUL 2018. Web of Science Citations: 4.
FERNANDES, MIRIAM R.; SELLERA, FABIO P.; MOURA, QUEZIA; CARVALHO, MARCELO P. N.; ROSATO, PAULA N.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Zooanthroponotic Transmission of Drug-Resistant Pseudomonas aeruginosa, Brazil. Emerging Infectious Diseases, v. 24, n. 6, p. 1160-1162, JUN 2018. Web of Science Citations: 9.
SELLERA, FABIO P.; FERNANDES, MIRIAM R.; MOURA, QUEZIA; SOUZA, TIAGO A.; NASCIMENTO, CRISTIANE L.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Draft genome sequence of an extensively drug-resistant Pseudomonas aeruginosa isolate belonging to ST644 isolated from a footpad infection in a Magellanic penguin (Spheniscus magellanicus). JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 12, p. 88-89, MAR 2018. Web of Science Citations: 1.
TAMARIZ, JESUS; LLANOS, CARLOS; SEAS, CARLOS; MONTENEGRO, PAOLA; LAGOS, JOSE; FERNANDES, MIRIAM R.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Draft Genome Sequence of the First New Delhi Metallo-beta-Lactamase (NDM-1)-Producing Escherichia coli Strain Isolated in Peru. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 13 MAR 2018. Web of Science Citations: 1.
ESPOSITO, FERNANDA; FERNANDES, MIRIAM R.; LOPES, RALF; MUNOZ, MARIA; SABINO, CAETANO P.; CUNHA, MARCOS P.; SILVA, KETRIN C.; CAYO, RODRIGO; MARTINS, WILLAMES M. B. S.; MORENO, ANDREA M.; KNOBL, TEREZINHA; GALES, ANA C.; LINCOPAN, NILTON. Detection of Colistin-Resistant MCR-1-Positive Escherichia coli by Use of Assays Based on Inhibition by EDTA and Zeta Potential. Journal of Clinical Microbiology, v. 55, n. 12, p. 3454-3465, DEC 2017. Web of Science Citations: 19.
MOURA, QUEZIA; ESPOSITO, FERNANDA; FERNANDES, MIRIAM R.; ESPINOZA-MUNOZ, MARIA; SOUZA, TIAGO A.; SANTOS, SILVIA R.; CERDEIRA, LOUISE; CASSETTARI, VALERIA; LINCOPAN, NILTON. Genome sequence analysis of a hypermucoviscous/hypervirulent and MDR CTX-M-15/K19/ST29 Klebsiella pneumoniae isolated from human infection. PATHOGENS AND DISEASE, v. 75, n. 9 DEC 2017. Web of Science Citations: 3.
NASCIMENTO, TATIANE; CANTAMESSA, RODRIGO; MELO, LUANA; FERNANDES, MIRIAM R.; FRAGA, EDMIR; DROPA, MILENA; SATO, MARIA I. Z.; CERDEIRA, LOUISE; LINCOPAN, NILTON. International high-risk clones of Klebsiella pneumoniae KPC-2/CC258 and Escherichia coli CTX-M-15/CC10 in urban lake waters. Science of The Total Environment, v. 598, p. 910-915, NOV 15 2017. Web of Science Citations: 15.
CERDEIRA, LOUISE T.; CUNHA, MARCOS P. V.; FRANCISCO, GABRIELA R.; BUENO, MARIA FERNANDA C.; ARAUJO, BRUNA F.; RIBAS, ROSINEIDE M.; GONTIJO-FILHO, PAULO P.; KNOBL, TEREZINHA; GARCIA, DOROTI DE OLIVEIRA; LINCOPAN, NILTON. IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 89, n. 2, p. 164-167, OCT 2017. Web of Science Citations: 7.
LOPES, RALF; CERDEIRA, LOUISE T.; FERNANDES, MIRIAM R.; PEREZ-CHAPARRO, PAULA J.; MCCULLOCH, JOHN A.; LINCOPAN, NILTON. Draft genome sequence of a CTX-M-15-producing endophytic Klebsiella pneumoniae ST198 isolate from commercial lettuce. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 10, p. 19-20, SEP 2017. Web of Science Citations: 2.
MOURA, QUEZIA; FERNANDES, MIRIAM R.; CERDEIRA, LOUISE; SANTOS, ANA CAROLINA M.; DE SOUZA, TIAGO A.; IENNE, SUSAN; PIGNATARI, ANTONIO CARLOS C.; GALES, ANA C.; SILVA, ROSA M.; LINCOPAN, NILTON. Draft genome sequence of a multidrug-resistant Aeromonas hydrophila ST508 strain carrying rmtD and bla(CTX-M-131) isolated from a bloodstream infection. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 10, p. 289-290, SEP 2017. Web of Science Citations: 2.
SELLERA, FABIO P.; FERNANDES, MIRIAM R.; MOURA, QUEZIA; SOUZA, TIAGO A.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Draft genome sequence of Enterobacter cloacae ST520 harbouring bla(KPC-2), bla(CTX-M-15) and bla(OXA-17) isolated from coastal waters of the South Atlantic Ocean. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 10, p. 279-280, SEP 2017. Web of Science Citations: 7.
FERNANDES, MIRIAM R.; SELLERA, FABIO P.; ESPOSITO, FERNANDA; SABINO, CAETANO P.; CERDEIRA, LOUISE; LINCOPAN, NILTON. Colistin-Resistant mcr-1-Positive Escherichia coli on Public Beaches, an Infectious Threat Emerging in Recreational Waters. Antimicrobial Agents and Chemotherapy, v. 61, n. 7 JUL 2017. Web of Science Citations: 22.
MONTE, DANIEL FARIAS; MEM, ANDRESSA; FERNANDES, MIRIAM R.; CERDEIRA, LOUISE; ESPOSITO, FERNANDA; GALVAO, JULIA A.; FRANCO, BERNADETTE D. G. M.; LINCOPAN, NILTON; LANDGRAF, MARIZA. Chicken Meat as a Reservoir of Colistin-Resistant Escherichia coli Strains Carrying mcr-1 Genes in South America. Antimicrobial Agents and Chemotherapy, v. 61, n. 5 MAY 2017. Web of Science Citations: 30.
TURANO, HELENA; GOMES, FERNANDO; BARROS-CARVALHO, GESIELE A.; LOPES, RALF; CERDEIRA, LOUISE; NETTO, LUIS E. S.; GALES, ANA C.; LINCOPAN, NILTON. Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, v. 61, n. 5 MAY 2017. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

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